The Human and Molecular Development Training Grant supported the bench research of 27 Pediatrician Scientist Postdoctoral Fellows in the past 10 years. Without this funding, these fellows would not have had the opportunity to develop basic science research programs that serve as the foundation for their academic careers. At a time when there is a lack of pediatric subspecialists, the program supported fellows in Allergy/immunology/Rheumatology, Cardiology, Endocrinology, Gastroenterology, Genetics, Hematology/Oncology, and Infectious Disease. Fourteen of the 15 former fellows continue to practice their subspecialty. Of the 15 former fellows, 12 are assistant professors, one is a clinical instructor, and two are in private practice. Their faculty appointments are at Children's Hospital Orange County, Duke, Harbor-UCLA, Mattel Children's Hospital at UCLA, University of California at Irvine, UCSF, University of Texas Southwestern, and University of Wisconsin, Madison. Thirteen of the 15 former fellows continue to be actively involved in research, with a median time commitment of 75% effort. Trainees earned $6,446,800 in grant funding to date, including one F32, three other T32s, one Pediatric Scientist Development Program, five K08s, five K12s, one K22, one R01, and 30 private foundation grants. The program filled all four postdoctoral training slots for each year. All fellows spent two years on the training program unless they switched to another program to support their research to make room for more fellows on the training program. There are a number of excellent candidates for future support if this program is renewed.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007512-13
Application #
7840417
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Mukhopadhyay, Mahua
Project Start
1998-05-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
13
Fiscal Year
2010
Total Cost
$192,686
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Singh, R R; Yen, E Y (2018) SLE mortality remains disproportionately high, despite improvements over the last decade. Lupus 27:1577-1581
Yen, Eric Y; Shaheen, Magda; Woo, Jennifer M P et al. (2017) 46-Year Trends in Systemic Lupus Erythematosus Mortality in the United States, 1968 to 2013: A Nationwide Population-Based Study. Ann Intern Med 167:777-785
Rodriguez, Jorge A; Huerta-Yepez, Sara; Law, Ivy Ka Man et al. (2015) Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling. Cell Mol Gastroenterol Hepatol 1:610-630
Paharkova, Vladislava; Alvarez, Griselda; Nakamura, Hiromi et al. (2015) Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. Mol Cell Endocrinol 413:96-100
Wen, Andy Y; Landaw, Elliot M; Ochoa, Rachel et al. (2013) Increased abscess formation and defective chemokine regulation in CREB transgenic mice. PLoS One 8:e55866
Kumar, Anjuli R; Li, Xiaoxiao; Leblanc, James F et al. (2011) Proteomic analysis reveals innate immune activity in intestinal transplant dysfunction. Transplantation 92:112-9
Hoang, Phuong T; Park, Patricia; Cobb, Laura J et al. (2010) The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism 59:343-9
Wen, Andy Y; Sakamoto, Kathleen M; Miller, Lloyd S (2010) The role of the transcription factor CREB in immune function. J Immunol 185:6413-9
Tachdjian, Raffi; Al Khatib, Shadi; Schwinglshackl, Andreas et al. (2010) In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol 125:1128-1136.e8
Tachdjian, Raffi; Mathias, Clinton; Al Khatib, Shadi et al. (2009) Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med 206:2191-204

Showing the most recent 10 out of 16 publications