This training program is designed to prepare pediatricians for independent, research-oriented careers in academic medicine. Its specific goal is to provide young pediatric investigators with the powerful research tools of molecular and cellular biology that will allow them to explore, in depth, basic questions related to children's health. The 47 program faculty from across the University of Michigan are selected for their demonstrated excellence in training young investigators, the strength of their research programs, and their expertise in one of three areas of pediatric research -- host defenses, developmental biology, and abnormal cellular growth. The trainees supported by this program will be selected from a pool of individuals who have already completed the clinical component of fellowship training (one year) in one of the subspecialty areas of pediatrics. Criteria for choosing these trainees include their potential to be successful investigators, their previous academic records, and their commitment to developing independent, academically-oriented research careers. Each year the program will support five trainees;three to four will be supported in their first year of the research component of their fellowship training, and one to two in the second year. A curriculum is provided for the trainees that takes advantage of the rich educational and research opportunities available at the University of Michigan. Trainees will enroll in the intensive three-month postdoctorate course in Cellular and Molecular Biology offered by the Medical School, will participate in a statistics seminar sponsored by the Department of Pediatrics, in sessions to develop academic skills, in compliance educational modules sponsored by the Medical School, and will present their research at the annual Pediatric Research Day. The focus of the trainee's activities will be an individual research project in the laboratory of the research mentor. In addition, the trainees will participate in research seminars, lectures, and specialized workshops offered by the many basic and clinical sciences units of the University, and will have access to the excellent Medical School core laboratories. As part of their research experience, they will apply for individual awards to support completion of their research training. Progress of the trainees'research work will be monitored by the trainees'research committees;the Program Committee, composed of pediatric faculty;and the Advisory Committee, composed of Medical School faculty outside the Department of Pediatrics. Upon completion of their postdoctoral training, trainees will be board eligible in a pediatric clinical subspeciality, and will be well-prepared for successful careers as independent, research-oriented academic pediatricians.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Mukhopadhyay, Mahua
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Mohan, Smriti; Barsalou, Julie; Bradley, Timothy J et al. (2015) Endothelial progenitor cell phenotype and function are impaired in childhood-onset systemic lupus erythematosus. Arthritis Rheumatol 67:2257-62
Krook, Melanie A; Nicholls, Lauren A; Scannell, Christopher A et al. (2014) Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res 12:953-64
Saba, Thomas G; Chung, Yutein; Hong, Jun Young et al. (2014) Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol 50:974-84
Morris, David L; Singer, Kanakadurga; Lumeng, Carey N (2011) Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care 14:341-6
Selewski, David T; Cornell, Timothy T; Lombel, Rebecca M et al. (2011) Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy. Intensive Care Med 37:1166-73
Rosebeck, Shaun; Madden, Lisa; Jin, Xiaohong et al. (2011) Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science 331:468-72
Roy, Sumita; Raskin, Leon; Raymond, Victoria M et al. (2009) Pediatric duodenal cancer and biallelic mismatch repair gene mutations. Pediatr Blood Cancer 53:116-20
Pillai, P; Srinivasan, U; Zhang, L et al. (2009) Streptococcus agalactiae pulsed-field gel electrophoresis patterns cross capsular types. Epidemiol Infect 137:1420-5
Lumeng, Carey N; Deyoung, Stephanie M; Saltiel, Alan R (2007) Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab 292:E166-74
Lumeng, Carey N; Deyoung, Stephanie M; Bodzin, Jennifer L et al. (2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23

Showing the most recent 10 out of 15 publications