The Division of Pediatric Emergency Medicine at Children's Hospital Boston (CHB) has been, for the last 6 years, recipient of NRSA-T32 grant # HD40128-04 (Research Training in Pediatric Emergency Medicine). This renewal application seeks continued funding for a unique research training enterprise in pediatric emergency medicine. The Research Training Program was built on the CHB Division of Emergency Medicine's dedication to preparing pediatric emergentologists for research careers that will advance the field through the conduct of rigorous clinical, informatics, and basic science investigation. To date, 9 fellows have entered this Training Grant. All have remained in academic medicine as highly productive, funded investigators. Building on the success of the initial 6 years, the proposed continuation will maintain the Program Plan that has been responsible for the success of the program. Trainees will continue to have 3 research tracks available: clinical investigation, medical informatics, or basic science. The disciplines within clinical investigation will include clinical epidemiology, health outcomes, evidence-based protocols in bioterrorism/emergency preparedness, and patient safety. Disciplines within medical informatics will include data mining and modeling, automated decision support, and syndromic surveillance/public health informatics. Disciplines within basic science will include cellular and molecular biology, functional genomics/proteomics/ metabolomics, immunology/inflammation, and pharmacology/toxicology. The tools acquired through mastery of these disciplines will be applied to specific themes in pediatric emergency medicine. Two significant revisions are found in this renewal proposal: (1) extension of the research training period from two to three years, and (2) the addition of post-doctoral trainees. This application proposes funding for 6 post-residency and post-doctoral fellows. Research training will continue to take place under the mentorship of a group of outstanding investigators in the CHB/HMS and Greater Boston medical community. The broad, multidisciplinary, multi-site collaborations built within this Research Training Program will help to shape the research teams of the future, an established goal of the NIH Roadmap. Graduates of the Program, as well-trained physician-scientists, will be the chief architects in accelerating the pace of knowledge acquisition in the nascent subspecialty of pediatric emergency medicine.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Jenkins, Tammara L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital Boston
United States
Zip Code
Pigott, David M; Deshpande, Aniruddha; Letourneau, Ian et al. (2017) Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis. Lancet 390:2662-2672
Robinson, Shenandoah; Berglass, Jacqueline B; Denson, Jesse L et al. (2017) Microstructural and microglial changes after repetitive mild traumatic brain injury in mice. J Neurosci Res 95:1025-1035
Wojtowicz, Magdalena; Iverson, Grant L; Silverberg, Noah D et al. (2017) Consistency of Self-Reported Concussion History in Adolescent Athletes. J Neurotrauma 34:322-327
Liu, Xixia; Qiu, Jianhua; Alcon, Sasha et al. (2017) Environmental Enrichment Mitigates Deficits after Repetitive Mild Traumatic Brain Injury. J Neurotrauma 34:2445-2455
Geva, Alon; Olson, Karen L; Liu, Chunfu et al. (2017) Provider Connectedness to Other Providers Reduces Risk of Readmission After Hospitalization for Heart Failure. Med Care Res Rev :1077558717718626
Albayram, Onder; Kondo, Asami; Mannix, Rebekah et al. (2017) Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat Commun 8:1000
Conaway, Evan A; de Oliveira, Dalila C; McInnis, Christine M et al. (2017) Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol 198:2906-2915
Lyons, Todd W; Cruz, Andrea T; Freedman, Stephen B et al. (2017) Correction of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar Punctures. Pediatr Infect Dis J 36:1006-1008
Lyons, Todd W; Olson, Karen L; Palmer, Nathan P et al. (2017) Patients Visiting Multiple Emergency Departments: Patterns, Costs, and Risk Factors. Acad Emerg Med 24:1349-1357
Ong, Mei-Sing; Mullen, Mary P; Austin, Eric D et al. (2017) Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension. Circ Res 121:341-353

Showing the most recent 10 out of 103 publications