The Division of Pediatric Emergency Medicine at Children's Hospital Boston (CHB) has been, for the last 6 years, recipient of NRSA-T32 grant # HD40128-04 (Research Training in Pediatric Emergency Medicine). This renewal application seeks continued funding for a unique research training enterprise in pediatric emergency medicine. The Research Training Program was built on the CHB Division of Emergency Medicine's dedication to preparing pediatric emergentologists for research careers that will advance the field through the conduct of rigorous clinical, informatics, and basic science investigation. To date, 9 fellows have entered this Training Grant. All have remained in academic medicine as highly productive, funded investigators. Building on the success of the initial 6 years, the proposed continuation will maintain the Program Plan that has been responsible for the success of the program. Trainees will continue to have 3 research tracks available: clinical investigation, medical informatics, or basic science. The disciplines within clinical investigation will include clinical epidemiology, health outcomes, evidence-based protocols in bioterrorism/emergency preparedness, and patient safety. Disciplines within medical informatics will include data mining and modeling, automated decision support, and syndromic surveillance/public health informatics. Disciplines within basic science will include cellular and molecular biology, functional genomics/proteomics/ metabolomics, immunology/inflammation, and pharmacology/toxicology. The tools acquired through mastery of these disciplines will be applied to specific themes in pediatric emergency medicine. Two significant revisions are found in this renewal proposal: (1) extension of the research training period from two to three years, and (2) the addition of post-doctoral trainees. This application proposes funding for 6 post-residency and post-doctoral fellows. Research training will continue to take place under the mentorship of a group of outstanding investigators in the CHB/HMS and Greater Boston medical community. The broad, multidisciplinary, multi-site collaborations built within this Research Training Program will help to shape the research teams of the future, an established goal of the NIH Roadmap. Graduates of the Program, as well-trained physician-scientists, will be the chief architects in accelerating the pace of knowledge acquisition in the nascent subspecialty of pediatric emergency medicine.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD040128-10
Application #
8280150
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Jenkins, Tammara L
Project Start
2001-05-15
Project End
2013-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
10
Fiscal Year
2012
Total Cost
$152,565
Indirect Cost
$10,005
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Meehan 3rd, William P; Taylor, Alex M; Berkner, Paul et al. (2016) Division III Collision Sports Are Not Associated with Neurobehavioral Quality of Life. J Neurotrauma 33:254-9
Meehan 3rd, William P; O'Brien, Michael J; Geminiani, Ellen et al. (2016) Initial symptom burden predicts duration of symptoms after concussion. J Sci Med Sport 19:722-5
Kantor, David B; Stenquist, Nicole; McDonald, Molly C et al. (2016) Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children. J Allergy Clin Immunol 138:1467-1471.e9
Kantor, David B; Su, Erik; Milliren, Carly E et al. (2016) Ultrasound Guidance and Other Determinants of Successful Peripheral Artery Catheterization in Critically Ill Children. Pediatr Crit Care Med 17:1124-1130
Meehan 3rd, William; Mannix, Rebekah; Zafonte, Ross et al. (2015) Chronic traumatic encephalopathy and athletes. Neurology 85:1504-11
Kondo, Asami; Shahpasand, Koorosh; Mannix, Rebekah et al. (2015) Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature 523:431-6
Meehan 3rd, William P; Jordaan, Marc; Prabhu, Sanjay P et al. (2015) Risk of athletes with Chiari malformations suffering catastrophic injuries during sports participation is low. Clin J Sport Med 25:133-7
Bourgeois, Florence T; Olson, Karen L; Poduri, Annapurna et al. (2015) Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients. Paediatr Drugs 17:401-10
Meehan 3rd, William P; Mannix, Rebekah; Monuteaux, Michael C et al. (2014) Early symptom burden predicts recovery after sport-related concussion. Neurology 83:2204-10
Brown, Naomi J; Mannix, Rebekah C; O'Brien, Michael J et al. (2014) Effect of cognitive activity level on duration of post-concussion symptoms. Pediatrics 133:e299-304

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