Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. Injury to the central nervous system from these insults is the key determinant of unfavorable outcome. These neurological and multi- system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Research training in pediatric neurointensive care and resuscitation is best served by a parallel multidisciplinary and multi- departmental program. Our unique postdoctoral program at the Safar Center for Resuscitation Research, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates rigorous scientific investigation across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation. We train fellows in these pediatric disciplines in basic and clinical research in neurointensive care and resuscitation, linking them to senior scientists. In this competitive renewal application, funds are requested to support 4 positions each yr. Since its inception, the program has filled every position with high-quality fellows who have published numerous peer-reviewed papers and abstracts, and have won many awards. In the last funding cycle, 4 of the 6 graduated fellows have already acquired 5 K awards (two K12s, two K08s, and one K23);many have received advanced degrees. They are highly sought after as faculty;all are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. We use a bench-to-bedside approach supported by federally funded studies by our faculty. We capitalize on the unique interaction between the Safar Center and the training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Medicine and also take advantages of many unique resources and a Clinical and Translational Science Institute. The director, co-director, and mentors are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for career development and hypothesis testing. We integrate a curriculum in neurointensive care and involvement on a unique pediatric neurocritical care clinical service. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions and are trained in grantsmanship and research integrity. The program has had success in diversity recruitment, notably, in recruiting applicants with disabilities.

Public Health Relevance

Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. These neurological and multi-system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Our unique multidisciplinary and multi-departmental postdoctoral program at the Safar Center for Resuscitation Research and Children's Hospital of Pittsburgh, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates training of clinician scientists across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD040686-13
Application #
8470669
Study Section
Special Emphasis Panel (ZHD1-DSR-Z (KP))
Program Officer
Maholmes, Valerie
Project Start
2000-09-25
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$260,625
Indirect Cost
$20,010
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Shein, Steven L; Bell, Michael J (2016) The authors reply. Pediatr Crit Care Med 17:707-8
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Miller Ferguson, Nikki; Shein, Steven L; Kochanek, Patrick M et al. (2016) Intracranial Hypertension and Cerebral Hypoperfusion in Children With Severe Traumatic Brain Injury: Thresholds and Burden in Accidental and Abusive Insults. Pediatr Crit Care Med 17:444-50
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Shein, Steven L; Maul, Timothy M; Li, Hong et al. (2015) Surfactant Administration During Pediatric Extracorporeal Membrane Oxygenation. ASAIO J 61:682-7
Simon, Dennis W; Fink, Ericka L; Manole, Mioara D (2015) Pediatric Out-of-Hospital Cardiac Arrest Outcomes: A Case of Male/Female Inequality? Pediatr Crit Care Med 16:779-80
Newell, Elizabeth A; Exo, Jennifer L; Verrier, Jonathan D et al. (2015) 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res 1594:27-35
Osier, Nicole D; Carlson, Shaun W; DeSana, Anthony et al. (2015) Chronic Histopathological and Behavioral Outcomes of Experimental Traumatic Brain Injury in Adult Male Animals. J Neurotrauma 32:1861-82

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