This application seeks to renew an Institutional Research Training Grant that supports fellowship training in the Department of Pediatrics at Duke University Medical Center. The long-term objective of the training program is to foster the growth and development of pediatric investigators who are prepared to pursue independent academic careers examining important issues relevant to the health and wellbeing of children. The program will exploit the rich research and training resources at Duke University, including a cadre of faculty in pediatrics and other departments who share common research interests and frequent scholarly interactions. The program will generally provide funding for two years of investigation and will emphasize the application of cell and molecular biologic approaches and rigorous clinical and epidemiologic methods to improve our understanding of the processes that underlie pediatric diseases and to develop new and effective therapies for children. Trainees will have access to sufficient space and resources and will benefit from the extensive educational activities at Duke University, including didactic coursework, journal clubs, and relevant seminars. The principal investigator and the program director will receive assistance from an internal advisory board and an external advisory board to select candidate trainees, to review the scholarly progress of trainees, and to ensure the optimal operation of the program. The collaboration of established pediatric investigators and outstanding scientists in other departments who are pursuing questions relevant to pediatrics provides a unique opportunity for the training of pediatric fellows in the application of experimental methods to childhood diseases. As such, this program should foster the development of new pediatric scholars to lead the way for future advances in child health.

Public Health Relevance

There is a paramount need for individuals knowledgeable in clinical aspects of pediatrics and skilled in modern scientific methods who will develop novel approaches to the understanding and treatment of childhood diseases and who will thereby improve child health. The proposed training program will develop talented pediatric fellows into pediatric physician-scientists who will pursue independent academic careers and meet this need.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-D (59))
Program Officer
Winer, Karen
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Schools of Medicine
United States
Zip Code
Yin, Dwight E; Warshaw, Meredith G; Miller, William C et al. (2014) Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation. Pediatrics 134:e1104-16
Downey, L C; Benjamin Jr, D K; Clark, R H et al. (2013) Urinary tract infection concordance with positive blood and cerebrospinal fluid cultures in the neonatal intensive care unit. J Perinatol 33:302-6
Watt, Kevin; Manzoni, Paolo; Cohen-Wolkowiez, Michael et al. (2013) Triazole use in the nursery: fluconazole, voriconazole, posaconazole, and ravuconazole. Curr Drug Metab 14:193-202
Ozment, Caroline P; Mamo, Lisa B; Campbell, Mary Lee et al. (2013) Transfusion-related biologic effects and free hemoglobin, heme, and iron. Transfusion 53:732-40
Watt, Kevin M; Massaro, Matthew M; Smith, Brian et al. (2012) Pharmacokinetics of moxifloxacin in an infant with Mycoplasma hominis meningitis. Pediatr Infect Dis J 31:197-9
Watt, Kevin M; Cohen-Wolkowiez, Michael; Ward, Robert M et al. (2012) Commentary: pediatric antifungal drug development: lessons learned and recommendations for the future. Pediatr Infect Dis J 31:635-7
Piper, Lauren; Smith, P Brian; Hornik, Christoph P et al. (2011) Fluconazole loading dose pharmacokinetics and safety in infants. Pediatr Infect Dis J 30:375-8
Watt, Kevin; Li, Jennifer S; Benjamin Jr, Daniel K et al. (2011) Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation. J Cardiovasc Pharmacol 58:126-32
Watt, Kevin; Benjamin Jr, Daniel K; Cohen-Wolkowiez, Michael (2011) Pharmacokinetics of antifungal agents in children. Early Hum Dev 87 Suppl 1:S61-5
Wratney, Angela T; Benjamin Jr, Daniel Kelly; Slonim, Anthony D et al. (2008) The endotracheal tube air leak test does not predict extubation outcome in critically ill pediatric patients. Pediatr Crit Care Med 9:490-6

Showing the most recent 10 out of 11 publications