Biomedical research at the Oregon Health and Science University (OHSU) has expanded considerable over the past decade and, as part of this growth, the number of laboratories with a primary focus in embryonic development has increased greatly. To support the training efforts of these laboratories, this revised application is submitted to support a basic research training program that will provide predoctoral and postdoctoral students with a rigorous grounding in molecular and cellular aspects of Developmental Biology. The proposed training faculty is comprised of 23 investigators who utilize biochemical, molecular, cellular, and/or genetic approaches to understanding developmental processes in a variety of vertebrate and invertebrate animal model systems including flies, chick, frog, fish, and mouse. Program faculty are drawn from basic science departments and independent research units within the School of Medicine, all housed on the main OHSU campus. All members of the training faculty have active, externally funded basic research programs. The field of Developmental Biology is becoming increasingly intertwined with cell biology and other disciplines, requiring that students receive a broad education in diverse subjects in order to meet future challenges. To accomplish this, all trainees will receive rigorous research training in embryonic development in their preceptors'laboratories, and will participate in journal clubs, seminars, and scientific meetings, including the Northwest Regional Developmental Biology Meeting, the annual trainees symposium, and the OHSU graduate student retreat. Predoctoral trainees will also receive a broad classroom based education in biochemistry, genetics, cell biology, molecular biology, and neurobiology, as well as more in depth training in developmental biology through formal coursework involving both lectures and laboratory exercises. One outstanding feature of the training program at OHSU is the high level of interactions and collaborations that occur among faculty members with diverse research interests and expertise.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Javois, Lorette Claire
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Green, Yangsook Song; Kwon, Sunjong; Mimoto, Mizuho S et al. (2016) Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos. Development 143:4016-4026
Courter, Lauren A; Shaffo, Frances C; Ghogha, Atefeh et al. (2016) BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling. Dev Neurobiol 76:1003-13
Bolkan, Bonnie J; Kretzschmar, Doris (2014) Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila. Dev Neurobiol 74:1210-25
Drerup, Catherine M; Nechiporuk, Alex V (2013) JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet 9:e1003303
Clemens Grisham, Rachel; Kindt, Katie; Finger-Baier, Karin et al. (2013) Mutations in ap1b1 cause mistargeting of the Na(+)/K(+)-ATPase pump in sensory hair cells. PLoS One 8:e60866
Bolkan, Bonnie J; Triphan, Tilman; Kretzschmar, Doris (2012) ?-secretase cleavage of the fly amyloid precursor protein is required for glial survival. J Neurosci 32:16181-92
Mimoto, Mizuho S; Christian, Jan L (2011) Manipulation of gene function in Xenopus laevis. Methods Mol Biol 770:55-75
Powell, Anne E; Anderson, Eric C; Davies, Paige S et al. (2011) Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res 71:1497-505
Pratt, Emily B; Wentzell, Jill S; Maxson, Julia E et al. (2011) The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors. Acta Histochem 113:248-55
Zhang, Yonghong; Larsen, Christine A; Stadler, H Scott et al. (2011) Structural basis for sequence specific DNA binding and protein dimerization of HOXA13. PLoS One 6:e23069

Showing the most recent 10 out of 22 publications