This is the first renewal submission of an application for an NICHD Institutional Training Grant in Pediatric Emergency Medicine intended to provide the Department of Pediatrics at Washington University in St. Louis School of Medicine (WUMS) with the funds necessary to recruit and educate qualified physician-scientists. Our long-term objective is to use this funding to promote the career development of young physician scientists who will become future leaders in biomedical research efforts dedicated to improving health outcomes for children with emergency medical conditions.
The specific aims of this proposal are to identify potential trainees at the completion of their residency and to provide them with a two-year research experience in the laboratory of a qualified mentor or with a comparably rigorous mentored patient-oriented research experience, protected from clinical and teaching responsibilities. The focus of the research will be on child health issues in pediatric emergency medicine, including high-priority patient-oriented research with emphasis on the relationship between catastrophic illness, emergency care and long-term disabilities. We will also emphasize molecular mechanisms of infection and immunity, and multiple organ dysfunction syndrome (MODS) arising from traumatic or non-traumatic shock states. We will achieve this goal by creating two tracks: (1) patient-oriented research, and (2) the molecular mechanisms of infection, immunity, and MODS. Recent advances in cell, molecular, and developmental biology will be applied to understanding the pathogenesis and treatment of infection, immunity and MODS. Similarly rigorous patient-oriented research methods will be applied to improve outcomes of high-priority emergency medical and surgical diseases, using the full facilities of the WUMS and its Department of Pediatrics. We have in place a structure in which bright, motivated young pediatricians will flourish in a protected environment and will emerge as leaders in this evolving subspecialty of pediatrics. We plan to enroll one new post-doctoral fellow per year for a 5-year period. The proposed duration of training for each fellow is 2 years. The program takes advantage of 25 established investigators who will serve as mentors. The long-term goals will be realized as its trainees contribute to the development of and leadership as pediatric emergency physician-scientists during the next two or more decades.
This project is designed to fund one of only 2 training grants in Pediatric Emergency Medicine in the United States. The goal of this program is to train a cadre of Pediatric Emergency Physician- Scientists who will make discoveries in both basic and translational research that will lead to the improvement of health outcomes in children with emergency medical and surgical conditions. As the 2006 report of the Institute of Medicine stated "The payoff from increased pediatric emergency care research, while difficult to quantify, will include lives saved, decreased morbidity, and a more efficient and effective emergency care system."
|Ahmad, Fahd A; Jeffe, Donna B; Plax, Katie et al. (2014) Computerized self-interviews improve Chlamydia and gonorrhea testing among youth in the emergency department. Ann Emerg Med 64:376-84|
|Smith, Michelle I; Yatsunenko, Tanya; Manary, Mark J et al. (2013) Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science 339:548-54|
|Trehan, Indi; Goldbach, Hayley S; LaGrone, Lacey N et al. (2013) Antibiotics as part of the management of severe acute malnutrition. N Engl J Med 368:425-35|
|Wang, Richard J; Trehan, Indi; LaGrone, Lacey N et al. (2013) Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition. J Nutr Educ Behav 45:258-63|
|Chang, Cindy Y; Trehan, Indi; Wang, Richard J et al. (2013) Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery. J Nutr 143:215-20|
|Hu, Xinran; Yu, Jinsheng; Crosby, Seth D et al. (2013) Gene expression profiles in febrile children with defined viral and bacterial infection. Proc Natl Acad Sci U S A 110:12792-7|
|LaGrone, Lacey N; Trehan, Indi; Meuli, Gus J et al. (2012) A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children. Am J Clin Nutr 95:212-9|
|Weisz, Ariana; Meuli, Gus; Thakwalakwa, Chrissie et al. (2011) The duration of diarrhea and fever is associated with growth faltering in rural Malawian children aged 6-18 months. Nutr J 10:25|
|Oakley, Eleanor; Reinking, Jason; Sandige, Heidi et al. (2010) A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children. J Nutr 140:2248-52|
|Staat, Mary Allen; Stadler, Laura Patricia; Donauer, Stephanie et al. (2010) Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine 28:7947-55|
Showing the most recent 10 out of 14 publications