This resubmission application seeks to renew support for a training program that prepares highly qualified pediatricians to assume leadership positions as investigators in Pediatric Infectious Diseases. Based in the Division of Infectious Diseases at Boston Children's Hospital, the program takes advantage of the rich academic and research resources of Harvard Medical School, Harvard School of Public Health, and affiliated teaching hospitals to bring together outstanding didactic experiences and research opportunities relevant to infectious diseases of children. Support for four positions per year is requested. Pediatricians enter the program for a minimum of three years of integrated clinical and research training that includes at least two years of supervised research under the mentorship of a member of the teaching faculty. Research training of pediatricians is fully integrated with that of PhD postdoctoral trainees in the laboratories of the teaching faculty. The 31 members of the teaching faculty are accomplished investigators and experienced mentors chosen from the Division of Infectious Diseases at Boston Children's Hospital and affiliated units at other Harvard institutions. Under the guidance of the research mentor and the Program Steering Committee, an individualized curriculum is designed for each trainee in one of three broad areas of investigation: microbial pathogenesis, host response and vaccines, or epidemiology and health outcomes. Trainees in the epidemiology and health outcomes pathway have the opportunity to earn a Master of Public Health degree from the Harvard School of Public Health as an integral part of the training program. Trainees in the other pathways also receive training in epidemiology, biostatistics, clinical trial design, and analytic methods. All trainees have seminars and tutorials in grant preparation and scientific writing that supplement the mentored research experience. An individual Scholarship Oversight Committee is appointed for each trainee to monitor progress and to provide career guidance. During the second or third year, trainees are expected to present their work at national meetings, to prepare one or more manuscripts for publication, and, in most cases, to apply for a K08, K23, or other career development award to support the transition to independence as an investigator. During the initial five years of this training grant, 11 pediatrician trainees and 4 PhD postdoctoral fellows have been supported by the grant. Of the 13 fellowship program graduates during this period, 12 have academic faculty or government research appointments. Six have received competitive individual fellowship and/or grant awards including 5 K08 or K23 awards, 2 R21, 1 R03, and a New Innovator award from NIH.
The goal of the training program is to train pediatricians for careers as researchers who will address the present and future challenges of childhood infections. Well-trained investigators in Pediatric Infectious Diseases are urgently needed to meet the ongoing and emerging threats to child health of congenital HIV infection, childhood malaria and tuberculosis, diarrheal diseases, and respiratory infections-critical problems that are further complicated by increasing antimicrobial resistance and societal opposition to childhood vaccines.
|Sharp, Jared D; Singh, Atul K; Park, Sang Tae et al. (2016) Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses. PLoS One 11:e0152145|
|Pettengill, Matthew A; van Haren, Simon D; Li, Ning et al. (2016) Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naÃ¯ve B cells. Innate Immun 22:433-43|
|Wang, Marie E; Patel, Archana B; Hansen, Nellie I et al. (2016) Risk factors for possible serious bacterial infection in a rural cohort of young infants in central India. BMC Public Health 16:1097|
|Croft, Lindsay D; Liquori, Michael E; Ladd, James et al. (2016) Frequency of Adverse Events Before, During, and After Hospital Admission. South Med J 109:631-635|
|Rakoff-Nahoum, Seth; Kong, Yong; Kleinstein, Steven H et al. (2015) Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Proc Natl Acad Sci U S A 112:1929-36|
|Ramirez-Avila, Lynn; Regan, Susan; Chetty, Senica et al. (2015) HIV testing rates, prevalence, and knowledge among outpatients in Durban, South Africa: Time trends over four years. Int J STD AIDS 26:704-9|
|Kinlay, Joanne; Flaherty, Kathleen; Scanlon, Patricia et al. (2015) Barriers to the use of face protection for standard precautions by health care providers. Am J Infect Control 43:169-70|
|Smith, Daniel R; Maestre-Reyna, Manuel; Lee, Gloria et al. (2015) In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment. Proc Natl Acad Sci U S A 112:10491-6|
|Schwenk, Hayden; Ramirez-Avila, Lynn; Sheu, Shu-Hsien et al. (2014) Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review. Pediatr Infect Dis J 33:e99-105|
|Rakoff-Nahoum, Seth; Coyne, Michael J; Comstock, Laurie E (2014) An ecological network of polysaccharide utilization among human intestinal symbionts. Curr Biol 24:40-9|
Showing the most recent 10 out of 19 publications