The investigators propose to establish a new interdisciplinary predoctoral training program in Stem Cell Biology at the University of Minnesota. The Stem Cell Institute at the University of Minnesota was established in 1999 and forms a strong hub for a broad spectrum of stem cell-based research. As the field of stem cell biology continues to rapidly expand, significantly more trained investigators are needed to address both the basic biological questions in this field, as well as translate new stem cell-based therapies to clinical medicine. The overall aim of this Stem Cell Biology Training Program is to foster the career development of outstanding predoctoral trainees to enable them to develop successful stem cell-focused research careers. To achieve this aim, this proposed training program has assembled 25 outstanding faculty members from both biomedical science and engineering departments. Research opportunities involve a full-spectrum of work on animal and human models utilizing both pluripotent stem cells as well as adult tissue-specific stem cells. Faculty in this program have expertise in the full range of disciplines that are required to advance the stem cell research field, including: basic developmental biology, molecular biology/gene therapy, cell biology, immunology, biomedical engineering, clinical and veterinary medicine, as well as bioethics. Trainees in this program will complete graduate-level courses in stem cell biology, as well as related courses such as developmental biology. A central part of the training will be to engage in a research project in stem cell biology, and participate in Stem Cell Institute research conferences, journal clubs, and symposia. Trainees will be selected by the program Steering Committee on a competitive basis. Faculty members from ten different graduate programs are to mentor a strong pool of predoctoral trainee candidates. Together, these components will provide the comprehensive training in stem cell biology required to address the need for investigators with the knowledge and expertise to move forward both the basic biological studies of stem cells and translation to novel stem cell-based clinical therapies.
Stem cell biology provides the opportunity to produce new cell-based therapies to better treat and cure a range of diseases caused by cell and tissue degeneration or injury. These diseases consist of many where there are currently no good curative options, including but not limited to diabetes, Parkinson's disease, and other neurological disorders, malignancies, and cardiovascular injury.
|Chan, John D; Agbedanu, Prince N; Grab, Thomas et al. (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. PLoS Negl Trop Dis 9:e0004063|
|Weidenhamer, Nathan K; Moore, Dusty L; Lobo, Fluvio L et al. (2015) Influence of culture conditions and extracellular matrix alignment on human mesenchymal stem cells invasion into decellularized engineered tissues. J Tissue Eng Regen Med 9:605-18|
|Gearhart, Micah D; Erickson, Jami R; Walsh, Andrew et al. (2015) Identification of Conserved and Novel MicroRNAs during Tail Regeneration in the Mexican Axolotl. Int J Mol Sci 16:22046-61|
|Ferrell, Patrick I; Xi, Jiafei; Ma, Chao et al. (2015) The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells. Stem Cells 33:1130-41|
|Erickson, Jami R; Echeverri, Karen (2015) In vivo modulation and quantification of microRNAs during axolotl tail regeneration. Methods Mol Biol 1290:159-67|
|Zhang, Teng; Murphy, Mark W; Gearhart, Micah D et al. (2014) The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Development 141:3662-71|
|Ni, Zhenya; Knorr, David A; Bendzick, Laura et al. (2014) Expression of chimeric receptor CD4Î¶ by natural killer cells derived from human pluripotent stem cells improves in vitro activity but does not enhance suppression of HIV infection in vivo. Stem Cells 32:1021-31|
|Chan, John D; Agbedanu, Prince N; Zamanian, Mostafa et al. (2014) 'Death and axes': unexpected CaÂ²âº entry phenologs predict new anti-schistosomal agents. PLoS Pathog 10:e1003942|
|Holzapfel, Keli L; Tyznik, Aaron J; Kronenberg, Mitchell et al. (2014) Antigen-dependent versus -independent activation of invariant NKT cells during infection. J Immunol 192:5490-8|
|Ferrell, Patrick I; Hexum, Melinda K; Kopher, Ross A et al. (2014) Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev 23:1355-63|
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