There is a profound need for newly trained physician/scientists to enter academic careers in Neonatology. The Division of Neonatology at Rainbow Babies &Children's Hospital has, for several decades, trained fellowship graduates to assume national and international leadership roles in Neonatology. We are proud of our accomplishments in the initial funding cycle of this T32 which include placement of all five T32 fellows in academic faculty careers, and a marked increase in the pool of TGE applicants. In this proposal we will enable trainees to address a broad spectrum of neonatal morbidities by focusing on our existing scientific strengths in respiratory neurobiology, brain development, and neurodevelopmental outcome and inflammation. We have an accomplished M.D. and Ph.D. mentoring faculty with scientific expertise in these three thematic areas, encompassing both basic translational and patient oriented research. We will recruit trainees to a two-year intensive research immersion under the mentorship of established investigators within one of these thematic areas. A mentorship committee may include "near peer" junior faculty preceptors to serve as trainee role models in addition to senior faculty mentors. As the primary mentor experience of the trainee is critical for success, we have chosen mentoring faculty with a strong track record for physician/scientist training, and will provide close monitoring of the trainee/mentorship relationship. Trainees will be exposed to a well structured didactic program to provide all the necessary skills for academic career development. Optional curricular activities will be designed for the chosen field of basic science or epidemiologic research [e.g., award of a Masters of Science degree in Clinical Research]. Oversight will occur via both stringent Internal Steering Committee review and an External Review Committee of highly regarded academic leaders in Neonatology. New strategies have been initiated to recruit minority and otherwise disadvantaged candidates to ensure a diversity of trainees committed to a successful transition from fellowship to basic translational or patient-oriented research focused on improving neonatal health. In summary, we are poised to build upon the success of our prior T32 funding cycle by incorporating new experienced investigators into the existing pool of mentors, all of whom are focused on neurorespiratory maturation and inflammatory pathways that contribute to resultant morbidities. resultant morbidities.

Public Health Relevance

This proposal seeks to continue our training of physicians to specialize in research devoted to disorders arising out of the newborn period. The focus of their research will relate to both clinical outcomes and basic biologic mechanisms with an emphasis on normal and abnormal lung and brain development, and factors that might disturb that development. Our objective is to develop young physician/scientists to pursue careers in academic medical centers with a significant research focus.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Raju, Tonse N
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
Schools of Medicine
United States
Zip Code
Raffay, Thomas; Kc, Prabha; Reynolds, James et al. (2014) Repeated ?2-adrenergic receptor agonist therapy attenuates the response to rescue bronchodilation in a hyperoxic newborn mouse model. Neonatology 106:126-32
Wang, Katherine; Difiore, Juliann M; Martin, Richard J et al. (2013) Markers for severity of illness associated with decreased snoring in toddlers born ELGA. Acta Paediatr 102:e39-43
Payne, Allison H; Hintz, Susan R; Hibbs, Anna Maria et al. (2013) Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA Pediatr 167:451-9