This is an application to re-establish a mentored training program for pediatric subspecialty fellows interested in research careers involving basic or translational research. The program offers a 2-year experience dedicated to training in cell/molecular biology or translational research that is relevant to child health for 4 fellows per year and is designed to serve as a launch for a career that ultimately as an NIH R01-funded pediatric physician scientist. One of the key features of this program is that is can be used for training of fellows in a number of subspecialties within the Department of Pediatrics of the University of Pittsburgh that do not have a T32 grant (Allergy/Immunology;Cardiology;Genetics;Hematology/Oncology;Infectious Diseases;Newborn Medicine;Pulmonology). Thus, it can maximize the extramural support by targeting the most talented fellows and matching them with outstanding mentors. The mentoring faculty includes 25 outstanding researchers who have a distinguished record of research contributions and mentoring. The philosophical emphasis of this mentoring experience is fundamentals of the scientific method combined with the highest standard of excellence for rigor and integrity because we believe these are the characteristics of the training experience that are most likely to lead to a long successful career Each of the Scholars is expected to carry out a challenging research project in the laboratory of one of the faculty mentors leading to publications as well as an application for their own K08, K23 or K99/R00 grant. The Department of Pediatrics at Pitt has one of the fastest growing pediatric research programs in the country and is based on a new Children's Hospital of Pittsburgh of UPMC campus with the new 300,000-square-foot CHP Rangos Pediatric Research Building. Based on these characteristics and our previous training results, we believe that this program provides a powerful team of mentors and intellectually-rich environment that will inspire pediatric subspecialty fellows and provide them with the background to become successful child health researchers.

Public Health Relevance

All of the training experiences in this program involve research on mechanisms of human diseases including neurodevelopmental disorders, inborn errors of metabolism, congenital anomalies, infections, shock, cancer, cystic fibrosis, hypertensive kidney disease, transplant tolerance, immune disorders, chronic obstructive pulmonary disease, diabetes and disorders of the premature newborn.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD071834-02
Application #
8626425
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Winer, Karen
Project Start
2013-05-01
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Tsiarli, M A; Rudine, A; Kendall, N et al. (2017) Antenatal dexamethasone exposure differentially affects distinct cortical neural progenitor cells and triggers long-term changes in murine cerebral architecture and behavior. Transl Psychiatry 7:e1153
Jackson, Laura E; Kulkarni, Sucheta; Wang, Huabo et al. (2017) Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation. Cancer Res 77:5795-5807
Khan, Zahida; Strom, Stephen C (2017) Hepatocyte Transplantation in Special Populations: Clinical Use in Children. Methods Mol Biol 1506:3-16
Khan, Zahida; Orr, Anne; Michalopoulos, George K et al. (2017) Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. Pediatr Dev Pathol 20:16-27
Frahm, Krystle A; Waldman, Jacob K; Luthra, Soumya et al. (2017) A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol :
Khan, Zahida; Yokota, Shinichiro; Ono, Yoshihiro et al. (2017) Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of ?-1 Antitrypsin Deficiency. Gene Expr 17:115-127
Brooks, Merrian J; Bear, Todd; Hacker, Karen et al. (2017) An Alternative Technique for Youth Risk Surveillance Outside of the School System. J Adolesc Health 60:72-78
Khan, Zahida; Venkat, Veena L; Soltys, Kyle A et al. (2017) A Challenging Case of Severe Infantile Cholestasis in Alpha-1 Antitrypsin Deficiency. Pediatr Dev Pathol 20:176-181
Medsker, Brock H; Brew, Bronwyn K; Forno, Erick et al. (2017) Maternal depressive symptoms, maternal asthma, and asthma in school-aged children. Ann Allergy Asthma Immunol 118:55-60.e1
Wang, Huabo; Lu, Jie; Edmunds, Lia R et al. (2016) Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem 291:26241-26251

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