This is an application for renewal of the Institutional Training Grant, Graduate Research Training in Neonatal Translational Research. The goal of this interdisciplinary Program of the Department of Pediatrics at the University of California San Francisco (UCSF) is to provide comprehensive postdoctoral training and mentored career development for pediatricians with MD or MD, PhD degrees committed to an academic career with a strong component in basic laboratory-to-human subjects (T1) or evidence-to-practice (T2) research. This Program stems from a previous 30-year old NICHD-funded joint training program (Maternal-Fetal and Neonatal-Perinatal Medicine), in which >70% of graduates remain productive researchers and academic leaders in their respective fields. This application focuses on neonatologists-in-training, providing new and enhanced training opportunities in the neurosciences, stem cell biology, epidemiology and clinical investigation relevant to human development and neonatal disorders. The key elements of the proposed training are: (1) a mentored research experience, (2) scientific course work, (3) career development workshops, (4) interdisciplinary experiences and (5) continuing review and evaluation. The program provides two years of advanced research training for a total of three fellows. Thirty-four exceptionally well-qualified faculty members have committed their support as research mentors for this program that have combined NIH support of over 83 million dollars. All fellows will take courses in Responsible Conduct in Research, Scientific Writing and the Art of Lecturing. The fellow and research mentor determine additional course work in the specific field of research. A mentoring committee supports Fellows in setting and monitoring progress towards research and career goals. The Program Advisory Committee, comprising prominent UCSF investigators, active mentors and a distinguished External Reviewer, performs annual evaluation of all Fellows and the Program.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD071860-04
Application #
8846634
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Raju, Tonse N
Project Start
2012-05-01
Project End
2016-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
4
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Shiow, Lawrence R; Favrais, Geraldine; Schirmer, Lucas et al. (2017) Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury. Glia 65:2024-2037
Clyman, Ronald I; Liebowitz, Melissa (2017) Treatment and Nontreatment of the Patent Ductus Arteriosus: Identifying Their Roles in Neonatal Morbidity. J Pediatr 189:13-17
Muench, Marcus O; Kapidzic, Mirhan; Gormley, Matthew et al. (2017) The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation. Development 144:1399-1411
Keller, Roberta L; Feng, Rui; DeMauro, Sara B et al. (2017) Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study. J Pediatr 187:89-97.e3
Liebowitz, Melissa; Clyman, Ronald I (2017) Prophylactic Indomethacin Compared with Delayed Conservative Management of the Patent Ductus Arteriosus in Extremely Preterm Infants: Effects on Neonatal Outcomes. J Pediatr 187:119-126.e1
Liebowitz, Melissa; Koo, Jane; Wickremasinghe, Andrea et al. (2017) Effects of Prophylactic Indomethacin on Vasopressor-Dependent Hypotension in Extremely Preterm Infants. J Pediatr 182:21-27.e2
Liebowitz, Melissa; Clyman, Ronald I (2016) Antenatal Betamethasone: A Prolonged Time Interval from Administration to Delivery Is Associated with an Increased Incidence of Severe Intraventricular Hemorrhage in Infants Born before 28 Weeks Gestation. J Pediatr 177:114-120.e1
Liebowitz, Melissa C; Clyman, Ronald I (2016) Predicting the Need for Home Oxygen Therapy in Preterm Infants Born Before 28 Weeks' Gestation. Am J Perinatol 33:34-9
Basta, Amaya M; Lusk, Leslie A; Keller, Roberta L et al. (2016) Fetal Stomach Position Predicts Neonatal Outcomes in Isolated Left-Sided Congenital Diaphragmatic Hernia. Fetal Diagn Ther 39:248-55
Ponder, Kathryn L; Bárcena, Alicia; Bos, Frank L et al. (2016) Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche. Reprod Sci 23:1179-92

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