Turning the data collected by the recent quantum leap in DNA sequencing technology into useful biomedical knowledge is one of the greatest scientific challenges of the 21st Century. The enormous volume of DNA data now collected cannot be accessed, manipulated, or analyzed without computers. However, the greatest bottlenecks involve software rather than hardware. In spite of current levels of sophistication, we still lack adequate theory and algorithms to perform many fundamental tasks in molecular genetics and genetic epidemiology with speed and precision. It will take a new generation of scientists trained in both the biological and mathematical sciences to push forward our nation's genomic agenda. Few universities have the infrastructure and human resources to mount a genomic analysis training program of the scope possible at UCLA. Our training program's core curriculum includes work in molecular biology, human genetics, probability and statistics, bioinformatics, and biomedical ethics. Students must also prepare for and attend pertinent weekly scientific seminars. The trainees collectively meet on a monthly basis with the program faculty and directors to learn about career matters not covered in regular coursework. Each year we will train 12 predoctoral students drawn preferentially from students in the first half of their doctoral programs. Each trainee will be funded for two years contingent on satisfactory progress. In exceptional cases a third year of funding will be considered. This training grant has brought together faculty from four schools and 14 PhD-granting departments within the university to address the current gap in scientific training. During the years 2002 to 2010, this training grant has successfully completed training of 22 predoctoral students in the art of genomic analysis and interpretation. These doctorates have gone on to productive careers in genomic sciences in industry, government, and academia.

Public Health Relevance

Genetics is now a major driving force for modern biomedical research. As genetic experiments become more automated and miniaturized, data analysis and interpretation become the biggest bottlenecks to discovery. This program seeks to train a new generation of computational geneticists able to turn this flood of data into useful biomedical knowledge.

National Institute of Health (NIH)
National Human Genome Research Institute (NHGRI)
Institutional National Research Service Award (T32)
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Ethical, Legal, Social Implications Review Committee (GNOM)
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Junkins, Heather
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Kusters, Cynthia D J; Paul, Kimberly C; Guella, Ilaria et al. (2017) Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease. Parkinsonism Relat Disord :
Lin, Jer-Young; Le, Brandon H; Chen, Min et al. (2017) Similarity between soybean and Arabidopsis seed methylomes and loss of non-CG methylation does not affect seed development. Proc Natl Acad Sci U S A 114:E9730-E9739
Thompson, Michael J; vonHoldt, Bridgett; Horvath, Steve et al. (2017) An epigenetic aging clock for dogs and wolves. Aging (Albany NY) 9:1055-1068
Beichman, Annabel C; Phung, Tanya N; Lohmueller, Kirk E (2017) Comparison of Single Genome and Allele Frequency Data Reveals Discordant Demographic Histories. G3 (Bethesda) 7:3605-3620
Keys, Kevin L; Chen, Gary K; Lange, Kenneth (2017) Iterative hard thresholding for model selection in genome-wide association studies. Genet Epidemiol 41:756-768
Duong, Dat; Zou, Jennifer; Hormozdiari, Farhad et al. (2016) Using genomic annotations increases statistical power to detect eGenes. Bioinformatics 32:i156-i163
Men, Yujie; Han, Ping; Helbling, Damian E et al. (2016) Biotransformation of Two Pharmaceuticals by the Ammonia-Oxidizing Archaeon Nitrososphaera gargensis. Environ Sci Technol 50:4682-92
Gold, David A; Grabenstatter, Jonathan; de Mendoza, Alex et al. (2016) Sterol and genomic analyses validate the sponge biomarker hypothesis. Proc Natl Acad Sci U S A 113:2684-9
Chen, Haodong; Orozco, Luz D; Wang, Jessica et al. (2016) DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circ Res 118:786-97
Zhang, Wenjuan; Taylor, S Paige; Nevarez, Lisette et al. (2016) IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome. Hum Mol Genet 25:4012-4020

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