This application is to support a training program in the area of Genomics and Proteomics and related technologies. During the previous funding period we have established a training program in this area that supports six-seven predoctoral students and three postdoctoral fellows. Predoctoral trainees have a Bachelor's degree in a relevant field including the biological sciences and/or computer science. Students enter through a combined University-wide recruiting program. They take relevant courses in the area and will be closely advised by a faculty advising committee and an Executive Committee that oversees the entire program. Students will select a thesis advisor from among the thirty two faculty G&P trainers for their dissertation research. It is expected that predoctoral trainees will require 5-6 years for completion of their thesis research. At the end of their research they should be versatile in the field. Postdoctoral fellows will have a Ph.D. in a relevant field and directly join a G&P faculty laboratory. They will be closely mentored to obtain appropriate training in genomics and proteomics and relevant technologies. It is expected that upon completion of their training they will embark on an independent research career. Important features of the program include monthly meetings of the participants (predoctoral fellows, postdoctoral fellows and faculty) and relevant symposia in Genomics and Proteomics that actively involves the trainees. There will also be special programs for attracting and retaining minority trainees, and educational programs for ethical issues.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Institutional National Research Service Award (T32)
Project #
3T32HG003198-10S1
Application #
8814307
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Junkins, Heather
Project Start
2004-07-22
Project End
2015-04-30
Budget Start
2013-06-01
Budget End
2015-04-30
Support Year
10
Fiscal Year
2014
Total Cost
$435,886
Indirect Cost
$25,177
Name
Yale University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Weicksel, Steven E; Mahadav, Assaf; Moyle, Mark et al. (2016) A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans. Development 143:3540-3548
Steinbach, Jill M; Seo, Young-Eun; Saltzman, W Mark (2016) Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization. Acta Biomater 30:49-61
Metheetrairut, C; Adams, B D; Nallur, S et al. (2016) cel-mir-237 and its homologue, hsa-miR-125b, modulate the cellular response to ionizing radiation. Oncogene :
Goldstein, Jill; Roth, Eve; Roberts, Natalie et al. (2015) Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Mol Biol Cell 26:3606-14
Popa, Andreea; Zhang, Wei; Harrison, Megan S et al. (2015) Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. PLoS Pathog 11:e1004699
Laursen, Willem J; Mastrotto, Marco; Pesta, Dominik et al. (2015) Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proc Natl Acad Sci U S A 112:1607-12
Gayle, Sophia; Pan, Yukun; Landrette, Sean et al. (2015) piggyBac insertional mutagenesis screen identifies a role for nuclear RHOA in human ES cell differentiation. Stem Cell Reports 4:926-38
Holt, Jonathan F; Kiedrowski, Megan R; Frank, Kristi L et al. (2015) Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta. Infect Immun 83:396-404
DiMaio, Daniel; Burd, Christopher G; Goodner, Kylia (2015) Riding the R Train into the Cell. PLoS Pathog 11:e1005036
Harris, Kimberly A; Lünse, Christina E; Li, Sanshu et al. (2015) Biochemical analysis of pistol self-cleaving ribozymes. RNA 21:1852-8

Showing the most recent 10 out of 24 publications