The University of California, Davis (UCD) Center for Comparative Respiratory Biology and Medicine (CCRBM) Training in Comparative Lung Biology and Medicine Program is designed to provide opportunities for 6 predoctoral and 3 postdoctoral trainees/year to become independent investigators in pulmonary research. The duration of training will depend on the individual trainee's prior experience and capabilities to transition to their own independent academic and/or research careers. Candidates will be selected with special efforts give to minority recruitment strategies. Predoctoral students and postdoctoral trainees will be selected from the pool of candidates applying to the Center's many graduate group programs and/or applying to individual training faculty members and with evidence of previous research training relevant to the Center's research activities and priorities. Strong emphasis will be given to broad scope lung research training activities, with emphasis on lung comparative biology and cellular and molecular mechanisms. Faculty preceptors will direct research training in five primary areas: 1) airway pathophysiology;2) lung toxopharmacology and toxogenetics, including inhalation toxicology;3) stem cell biology and regenerative lung biology and medicine;4) cell signaling and lung molecular biology, and 5) lung inflammation and immunology. The training program includes an organized core curriculum consisting of research training in: (a) scientific ethics and paper and grant writing strategies including statistics;(b) principals of lung pathobiology;(c) specialized lung imaging technologies;(d) basic principles of proteonomics and genomics;(e) transgenic cell and mouse technologies, and (f) stem cell biology and regenerative medicine. Research conferences include seminars and work-in-progress sessions to assess trainee progress. Throughout the training program, guiding committee is organized and career planning is stressed so the Program can be individualized to best achieve each trainee's personal goals. The Program is designed to be an advantage of the existing strengths of UC Davis, including well established collaboration between lung researchers in the School of Medicine and the School of Veterinary Medicine, a National Prirnate Research Center on campus, a mouse biology program with Jackson Laboratory on campus, sophisticated facilities for inhalation toxicology, a very strong clinical program in pulmonary and critical care medicine, newly established stem cell center, and an established track record of research training over a period of more than 30 years.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007013-35
Application #
8497536
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Tigno, Xenia
Project Start
1975-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
35
Fiscal Year
2013
Total Cost
$307,493
Indirect Cost
$26,814
Name
University of California Davis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Aksenov, Alexander A; Sandrock, Christian E; Zhao, Weixiang et al. (2014) Cellular scent of influenza virus infection. Chembiochem 15:1040-8
Linderholm, Angela L; Bratt, Jennifer M; Schuster, Gertrud U et al. (2014) Novel therapeutic strategies for adult obese asthmatics. Immunol Allergy Clin North Am 34:809-23
Clay, Candice C; Maniar-Hew, Kinjal; Gerriets, Joan E et al. (2014) Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium. PLoS One 9:e90401
Schivo, Michael; Aksenov, Alexander A; Linderholm, Angela L et al. (2014) Volatile emanations from in vitro airway cells infected with human rhinovirus. J Breath Res 8:037110
Schivo, Michael; Seichter, Felicia; Aksenov, Alexander A et al. (2013) A mobile instrumentation platform to distinguish airway disorders. J Breath Res 7:017113
Fermin Lee, Agnes; Chen, Huan-Yuan; Wan, Lei et al. (2013) Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines. Am J Pathol 183:1209-22
Maniar-Hew, Kinjal; Clay, Candice C; Postlethwait, Edward M et al. (2013) Innate immune response to LPS in airway epithelium is dependent on chronological age and antecedent exposures. Am J Respir Cell Mol Biol 49:710-20
Grodzki, Ana Cristina G; Giulivi, Cecilia; Lein, Pamela J (2013) Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line. PLoS One 8:e54926
Williams, Keisha M; Franzi, Lisa M; Last, Jerold A (2013) Cell-specific oxidative stress and cytotoxicity after wildfire coarse particulate matter instillation into mouse lung. Toxicol Appl Pharmacol 266:48-55
Zeki, Amir A; Kenyon, Nicholas J; Goldkorn, Tzipora (2011) Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. Drug Metab Lett 5:40-4

Showing the most recent 10 out of 69 publications