The Nutrition, Obesity and Atherosclerosis Training Program at the University of Washington is a successful Training Program, now in its 35th year of funding. The overall goal of the program continues to be to provide a highly qualified group of postdoctoral MD clinicians and PhD scientists with the research skills they need to become fully independent biomedical investigators in the areas of nutrition, obesity and atherosclerosis. The training program utilizes 26 investigators at the University of Washington who are performing both basic and clinical research in these areas as preceptors. Use is also made of a number of basic and clinical scientists with whom the core faculty collaborates to broaden research opportunities and resources available to trainees in the program. Trainees entering the program previously have obtained either an MD or PhD degree and MD candidates usually have completed residency training. Some have had some prior research experience. PhD candidates have demonstrated ability in a basic science discipline and have demonstrated capability for research related to the focus of this program. Selection of the 4 candidates supported by this training grant is made by an Executive Committee from a large pool of qualified applicants who continue to apply for research training in metabolism, endocrinology and nutrition at the University of Washington. This program provides trainees with research experience in both basic and clinical science necessary in preparation for independent research careers. Appointments to the Training Program are for at least 2 years, with an optional 3rd year available. The program also includes opportunities for trainees to interact through program-specific meetings, and to present their research to peers, preceptors, and invited scientists from other academic institutions. A series of didactic lectures and seminars related to the topics of lipids, obesity, nutrition and atherosclerosis, as well as in scientific methods and biomedical ethics, complement the research training. Rigorous evaluation of trainees and preceptors is performed bi-annually and is overseen by the Executive Committee and an External Advisory Committee. The Nutrition, Obesity and Atherosclerosis Training Program has been highly successful in training productive scientists, including minority scientists, in these areas during the current funding period, and will provide an even stronger training environment due to several changes in overview, coherence, and training opportunities during the next funding period.
Nutrition and obesity are the major contributors to the cardiovascular disease epidemic in the United States and worldwide. A major reason for the increase in cardiovascular disease is the rapidly increasing prevalence of obesity in both adults and children, many of whom will develop cardiovascular disease, and so the burden on our society is tremendous. The Nutrition, Obesity and Atherosclerosis Training Program trains new generations of postdoctoral MD clinicians and PhD scientists to tackle these problems.
|Kocarnik, Beverly M; Boyko, Edward J; Matsumoto, Alvin M et al. (2016) Baseline estradiol concentration in community-dwelling Japanese American men is not associated with intra-abdominal fat accumulation over 10 years. Obes Res Clin Pract 10:624-632|
|Fujimoto, Wilfred Y (2016) 2015 Yutaka Seino Distinguished Leadership Award Lecture: The Japanese American Community Diabetes Study and the 'canary in the coal mine'. J Diabetes Investig 7:664-73|
|Henderson, Clark M; Lutsey, Pamela L; Misialek, Jeffrey R et al. (2016) Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D-Binding Protein in Blacks and Whites. Clin Chem 62:179-87|
|Hogan, Meghan F; Meier, Daniel T; Zraika, Sakeneh et al. (2016) Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro. Endocrinology 157:3462-8|
|Monette, Jeffrey S; Hutchins, Patrick M; Ronsein, Graziella E et al. (2016) Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle Concentration. Circ Res 119:83-90|
|Meier, Daniel T; Entrup, Leon; Templin, Andrew T et al. (2016) The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets. Diabetologia 59:2166-71|
|Henderson, Clark M; Vaisar, Tomas; Hoofnagle, Andrew N (2016) Isolating and Quantifying Plasma HDL Proteins by Sequential Density Gradient Ultracentrifugation and Targeted Proteomics. Methods Mol Biol 1410:105-20|
|Kaiyala, Karl J; Ogimoto, Kayoko; Nelson, Jarrell T et al. (2016) Physiological role for leptin in the control of thermal conductance. Mol Metab 5:892-902|
|Han, Chang Yeop; Tang, Chongren; Guevara, Myriam E et al. (2016) Serum amyloid A impairs the antiinflammatory properties of HDL. J Clin Invest 126:266-81|
|Lutsey, Pamela L; Parrinello, Christina M; Misialek, Jeffrey R et al. (2016) Short-term Variability of Vitamin D-Related Biomarkers. Clin Chem 62:1647-1653|
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