This training grant has been an excellent and productive program for 30 years. It will continue to provide the same high quality postdoctoral training in biomedical research in Blood Systems in Coagulation and Vessel Disease. This training grant will provide postdoctoral fellows the opportunity to train for two to three years in 24 different research programs whose Principal Investigators devote 100 percent of their time to basic research. TSRI has maintained its commitment to training the next generation of scientists, in part, by its active recruitment of postdoctoral fellows, all of whom have completed postgraduate degrees. These fellows continue their scientific training in TSRI's laboratories for a period of two to five years under the supervision of the senior scientific staff. They contribute to ongoing research inquiries and are named authors on numerous scientific publications. Trainees are recruited via multiple routes to attract as many candidates as possible from diverse ethnic, geographic and scientific disciplines. Study of cellular and soluble components of the vasculature is the unique cohesive theme of this NHLBI program. Cardiovascular disease and cancer are major public health issues. Functional aspects of hemostasis and blood vessel disease are studied in blood proteins, platelets, leukocytes and tissues. The common goal of the carefully chosen faculty is to understand at a basic molecular level how the vasculature functions to transport, regulate and protect the whole organism. This goal will be pursued through interdisciplinary collaborations among investigators in three different departments within the Institute. Special emphasis will be placed on use of new emerging disciplines including knock out and transgenic animals, intracellular signaling pathways, gene array approaches, proteomics and saturation mutagenesis. The success of this program has been excellent. The training experience is and will continue to be competitive and geared toward the development of self-directed researchers, yet will be enriched by cooperation and communication among scientists of diverse backgrounds.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-J (O1))
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Scripps Research Institute
La Jolla
United States
Zip Code
Deryugina, Elena I; Quigley, James P (2015) Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. Matrix Biol 44-46:94-112
Yokota, N; Zarpellon, A; Chakrabarty, S et al. (2014) Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. J Thromb Haemost 12:71-81
Miles, Lindsey A; Lighvani, Shahrzad; Baik, Nagyung et al. (2014) New insights into the role of Plg-RKT in macrophage recruitment. Int Rev Cell Mol Biol 309:259-302
Hosking, Martin P; Flynn, Claudia T; Whitton, J Lindsay (2014) Antigen-specific naive CD8+ T cells produce a single pulse of IFN-? in vivo within hours of infection, but without antiviral effect. J Immunol 193:1873-85
Teijaro, John R; Ng, Cherie; Lee, Andrew M et al. (2013) Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340:207-11
Hosking, Martin P; Flynn, Claudia T; Botten, Jason et al. (2013) CD8+ memory T cells appear exhausted within hours of acute virus infection. J Immunol 191:4211-22
Ochala, Julien; Gokhin, David S; Pénisson-Besnier, Isabelle et al. (2012) Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms. Hum Mol Genet 21:4473-85
Yamashiro, Sawako; Gokhin, David S; Kimura, Sumiko et al. (2012) Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types. Cytoskeleton (Hoboken) 69:337-70
Ng, Cherie T; Nayak, Bishnu P; Schmedt, Christian et al. (2012) Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection. Proc Natl Acad Sci U S A 109:7823-8
Kemball, Christopher C; Flynn, Claudia T; Hosking, Martin P et al. (2012) Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology 429:74-90

Showing the most recent 10 out of 90 publications