This Program is dedicated to the training of cardiovascular scientists with MD and/or PhD degrees. Over the past 20 years, the program has focused on producing new leaders in fundamental cardiovascular science. Areas of investigation include developmental biology, signal transduction, vascular and myocardial biology, complex multigenic disorders, molecular imaging, cardiac stem cell biology, metabolomics, and high-throughput chemical genetic screening. Graduates of the Training Program have been highly successful in terms of publications in high-profile journals, obtaining extramural funding, and securing outstanding faculty positions. The program is based at the Cardiovascular Research Center at the Massachusetts General Hospital with additional training sites at Harvard Medical School and Harvard University, as well as the Massachusetts Institute of Technology and the Broad Institute. New faculty have been recruited to enable trainees to benefit from dramatic recent advances in cardiovascular science, including genome wide association studies and induced pluripotent stem cells. The new faculty members are recognized leaders in their evolving fields, as well as proven, outstanding mentors. Training is firmly centered on laboratory science under the supervision of skilled primary and secondary mentors, with unique opportunities for innovation at the interface between fields and supervised development of interdisciplinary collaborative skills. Didactic experiences are tailored to the needs of the trainee and are designed to broaden their exposure to the forefront of cardiovascular science and provide science """"""""survival skills"""""""". The faculty and trainees are closely linked by the tradition of collaboration and a shared training mission. Importantly, an enhanced CVRC seminar series, CVRC retreat, and Science Social/Hot Topics meetings serve to bring trainees together on a regular basis and provide a sense of community. Trainee progress is closely monitored by the mentors, the Program Director and co-Directors, and a Steering Committee, with additional advice provided by an External Advisory Committee. Outstanding mentorship is taught, evaluated, and celebrated. As demonstrated by the strong track record of this Training Program, graduates are rigorously and systematically prepared to lead independent research programs at the cutting edge of cardiovascular science for the coming decades.
This Program trains cardiovascular scientists with MD and/or PhD degrees to lead independent research programs at the cutting edge of fundamental cardiovascular science. Research career development centers on experiences in the laboratory supplemented by coursework and seminars tailored to the trainee's experience and needs. The faculty and trainees are closely linked by a tradition of outstanding mentorship which is taught, evaluated, and celebrated.
|Clapham, Katharine R; Chu, Audrey Y; Wessel, Jennifer et al. (2016) A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. BMC Endocr Disord 16:7|
|Li, Xiang; Rhee, David K; Malhotra, Rajeev et al. (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest 126:389-401|
|Peloso, Gina M; Rader, Daniel J; Gabriel, Stacey et al. (2016) Phenotypic extremes in rare variant study designs. Eur J Hum Genet 24:924-30|
|Wu, Connie; Arora, Pankaj; Agha, Obiajulu et al. (2016) Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production. Mol Cell Biol 36:1977-87|
|Ye, Jiangchuan; Tucker, Nathan R; Weng, Lu-Chen et al. (2016) A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a. Am J Hum Genet 99:1281-1291|
|Jahangiri, Leila; Sharpe, Michka; Novikov, Natasha et al. (2016) The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development 143:113-22|
|Arora, Pankaj; Wu, Connie; Hamid, Tariq et al. (2016) Acute Metabolic Influences on the Natriuretic Peptide System in Humans. J Am Coll Cardiol 67:804-12|
|Khera, Amit V; Natarajan, Pradeep; Kathiresan, Sekar (2016) The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism? Eur J Prev Cardiol 23:1062-4|
|Tucker, Nathan R; Clauss, Sebastian; Ellinor, Patrick T (2016) Common variation in atrial fibrillation: navigating the path from genetic association to mechanism. Cardiovasc Res 109:493-501|
|Hucker, William J; Saini, Harsimran; Lubitz, Steven A et al. (2016) Atrial Fibrillation Genetics: Is There a Practical Clinical Value Now or in the Future? Can J Cardiol 32:1300-1305|
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