This Program is dedicated to the training of cardiovascular scientists with MD and/or PhD degrees. Over the past 20 years, the program has focused on producing new leaders in fundamental cardiovascular science. Areas of investigation include developmental biology, signal transduction, vascular and myocardial biology, complex multigenic disorders, molecular imaging, cardiac stem cell biology, metabolomics, and high-throughput chemical genetic screening. Graduates of the Training Program have been highly successful in terms of publications in high-profile journals, obtaining extramural funding, and securing outstanding faculty positions. The program is based at the Cardiovascular Research Center at the Massachusetts General Hospital with additional training sites at Harvard Medical School and Harvard University, as well as the Massachusetts Institute of Technology and the Broad Institute. New faculty have been recruited to enable trainees to benefit from dramatic recent advances in cardiovascular science, including genome wide association studies and induced pluripotent stem cells. The new faculty members are recognized leaders in their evolving fields, as well as proven, outstanding mentors. Training is firmly centered on laboratory science under the supervision of skilled primary and secondary mentors, with unique opportunities for innovation at the interface between fields and supervised development of interdisciplinary collaborative skills. Didactic experiences are tailored to the needs of the trainee and are designed to broaden their exposure to the forefront of cardiovascular science and provide science "survival skills". The faculty and trainees are closely linked by the tradition of collaboration and a shared training mission. Importantly, an enhanced CVRC seminar series, CVRC retreat, and Science Social/Hot Topics meetings serve to bring trainees together on a regular basis and provide a sense of community. Trainee progress is closely monitored by the mentors, the Program Director and co-Directors, and a Steering Committee, with additional advice provided by an External Advisory Committee. Outstanding mentorship is taught, evaluated, and celebrated. As demonstrated by the strong track record of this Training Program, graduates are rigorously and systematically prepared to lead independent research programs at the cutting edge of cardiovascular science for the coming decades.

Public Health Relevance

This Program trains cardiovascular scientists with MD and/or PhD degrees to lead independent research programs at the cutting edge of fundamental cardiovascular science. Research career development centers on experiences in the laboratory supplemented by coursework and seminars tailored to the trainee's experience and needs. The faculty and trainees are closely linked by a tradition of outstanding mentorship which is taught, evaluated, and celebrated.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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Massachusetts General Hospital
United States
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Nallamshetty, Shriram; Le, Phuong T; Wang, Hong et al. (2014) Retinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity. Bone 67:281-91
TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute; Crosby, Jacy; Peloso, Gina M et al. (2014) Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 371:22-31
Liu, Dajiang J; Peloso, Gina M; Zhan, Xiaowei et al. (2014) Meta-analysis of gene-level tests for rare variant association. Nat Genet 46:200-4
Peloso, Gina M; Auer, Paul L; Bis, Joshua C et al. (2014) Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet 94:223-32
Macri, Vincenzo; Mahida, Saagar N; Zhang, Michael L et al. (2014) A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation. Heart Rhythm 11:1055-62
Mahida, Saagar; Mills, Robert W; Tucker, Nathan R et al. (2014) Overexpression of KCNN3 results in sudden cardiac death. Cardiovasc Res 101:326-34
Tucker, Nathan R; Ellinor, Patrick T (2014) Emerging directions in the genetics of atrial fibrillation. Circ Res 114:1469-82
Tada, Hayato; Won, Hong-Hee; Melander, Olle et al. (2014) Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease. Circ Cardiovasc Genet 7:583-7
Asnani, Aarti; Peterson, Randall T (2014) The zebrafish as a tool to identify novel therapies for human cardiovascular disease. Dis Model Mech 7:763-7
Myocardial Infarction Genetics Consortium Investigators; Stitziel, Nathan O; Won, Hong-Hee et al. (2014) Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 371:2072-82

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