The program objective is to train promising new scientists in mechanisms of cardiovascular diseases, experimental strategies and technologies necessary for development of novel molecular therapeutics. The theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on molecular events in cardiovascular development, proteomics, cardiac stem cells and regenerative medicine as well as the molecular basis of cardiovascular disease. Future decades will see rapid advances in our understanding of the structure and function of molecules involved in cardiovascular disease and hopefully the successful application of these insights into the development of novel treatments and prevention of cardiovascular diseases. Such advances will require well-trained, energetic and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals that we intend to develop through the integrated predoctoral and postdoctoral components of this training program. The 36 mentor-eligible faculty members were selected on the basis of their research interests related to cardiovascular diseases, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to predoctoral and postdoctoral training. The Program Director and Co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of cardiovascular biology. Key components of the training program are the mentor research experience, required didactic courses providing a broad perspective of cardiovascular disease, required training and responsible conduct of research, elective courses, cardiovascular journal club, seminars, presentations at regional and national conferences, and professional development activities. The cardiovascular journal club, seminars, workshops, student research day, and annual cardiovascular retreat provide a framework for all trainees to interact, collaborate, and work together during their training experience. An integrative, multi-year evaluation plan is used to measure the extent to which the program goals and objectives are met.
Our aim i s to produce outstanding investigators with a broad insight into cardiovascular dysfunction who make significant contributions to the understanding of these disorders and development of therapies for cardiovascular diseases.

Public Health Relevance

/ PUBLIC HEALTH RELEVANCE The need for a highly trained workforce to address the treatment of cardiovascular disease continues to increase. Major demographic changes resulting from an aging population, elderly with chronic disease, and obesity are leading to increases in risk for cardiovascular events;interventional therapies and increasing survival rates are requiring more specialized treatments and follow-ups;and new technologies methodologies are requiring additional training in sophisticated procedures. This training grant will help train the next generation of scientists and clinician scientists engaged in cardiovascular research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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Medical University of South Carolina
Internal Medicine/Medicine
Schools of Medicine
United States
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Jesinkey, Sean R; Funk, Jason A; Stallons, L Jay et al. (2014) Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury. J Am Soc Nephrol 25:1157-62
Stallons, L Jay; Whitaker, Ryan M; Schnellmann, Rick G (2014) Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis. Toxicol Lett 224:326-32
Rahn, J J; Bestman, J E; Josey, B J et al. (2014) Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. Neuroscience 259:142-54
Wilkerson, Brent A; Argraves, Kelley M (2014) The role of sphingosine-1-phosphate in endothelial barrier function. Biochim Biophys Acta 1841:1403-1412
Eckhouse, Shaina R; Purcell, Brendan P; McGarvey, Jeremy R et al. (2014) Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction. Sci Transl Med 6:223ra21
Aune, Sverre E; Herr, Daniel J; Mani, Santhosh K et al. (2014) Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. J Mol Cell Cardiol 72:138-45
Czajka, Caitlin A; Mehesz, Agnes Nagy; Trusk, Thomas C et al. (2014) Scaffold-free tissue engineering: organization of the tissue cytoskeleton and its effects on tissue shape. Ann Biomed Eng 42:1049-61
Corum, Daniel G; Tsichlis, Philip N; Muise-Helmericks, Robin C (2014) AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J 28:395-407
Moschella, Phillip C; McKillop, John; Pleasant, Dorea L et al. (2013) mTOR complex 2 mediates Akt phosphorylation that requires PKCýý in adult cardiac muscle cells. Cell Signal 25:1904-12
Eckhouse, Shaina R; Jones, Jeffrey A; Spinale, Francis G (2013) Gene targeting in ischemic heart disease and failure: translational and clinical studies. Biochem Pharmacol 85:1-11

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