This renewal application requests support for a Training Program in Cardiovascular Biology, first established at Washington University in 1977, to support Predoctoral Students conducting Ph.D. thesis research and Postdoctoral Fellows in the early stages of post-graduate training. The goals of this Program are to provide outstanding research opportunities, well-rounded, multidisciplinary training in Modern Cardiovascular Biology, and mentoring to Predoctoral and Postdoctoral Trainees in the laboratories of the participating faculty to prepare these individuals to be productive, independent scientists. The critical components and the clear strengths of this Program are the 22 participating training faculty and the trainees themselves. Another important strength of this Program and, indeed, of the overall environment at Washington University, is the highly collaborative nature of our research efforts. This interactive environment and these collaborations expand the research, training and mentoring opportunities provided to the trainees. The faculty derive from multiple (6) Departments (Biochemistry, Biomedical Engineering, Cell Biology and Physiology, Developmental Biology, Medicicne and Radiology) and (4) Divisions (Cardiology, Chemistry, Endocrinology and Nutritional Science) within the Department of Medicine, and include nationally and internationally recognized leaders in several specific areas of Modern Cardiovascular Biology including molecular biology, physiology, cell biology, biochemistry, modeling, imaging, pathology, genetics, and human cardiovascular disease mechanisms. The faculty are well-established, well-funded, experienced and highly productive investigators, and all are committed to providing the training, experience, resources, intellectual enthusiasm and mentoring needed to achieve the overall goals of the Training Program and to facilitate the professional development of the individual Program Trainees. The strengths of this Program are manifest in the quantity and quality of our scientific output, in the quality of our present and past trainees, and in the achievements of our past trainees. In addition to the research training provided in individual and collaborating research laboratories, this Training Program provides instruction in "Ethics in Biomedical Research," and provides trainees the opportunity to participate in the "Core Cardiovascular Biology Curriculum," the weekly "Trainees in Cardiovascular Biology Series" and the weekly "Cardiovascular Research Seminar Series," all developed and operated by this Training Grant. This Training Program is also actively involved in monitoring the progress and professional development and in the mentoring of Predoctoral and Postdoctoral Trainees.

Public Health Relevance

This Program will provide outstanding research opportunities, training and mentoring to Predoctoral and Postdoctoral Trainees in Modern Cardiovascular Biology, including cardiovascular physiology, biochemistry, cell biology, genetics, imaging, modeling, and disease mechanisms. This Program will contribute to the training and professional development of the next generation of outstanding investigators focused on addressing important, unanswered questions in Cardiovascular Biology and Cardiovascular Disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Other Basic Sciences
Schools of Medicine
Saint Louis
United States
Zip Code
Peyrot, Sara M; Nachtergaele, Sigrid; Luchetti, Giovanni et al. (2014) Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. J Biol Chem 289:11095-110
Bielska, Agata A; Olsen, Brett N; Gale, Sarah E et al. (2014) Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry 53:3042-51
Mydock-McGrane, Laurel; Rath, Nigam P; Covey, Douglas F (2014) Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol. J Org Chem 79:5636-43
Bosch, Marie K; Nerbonne, Jeanne M; Ornitz, David M (2014) Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo. PLoS One 9:e104062
Vigueira, Patrick A; McCommis, Kyle S; Schweitzer, George G et al. (2014) Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Rep 7:2042-53
Devanathan, Sriram; Whitehead, Timothy; Schweitzer, George G et al. (2014) An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: functional, metabolic, and differential network analysis. PLoS One 9:e101900
Climer, Sharlee; Yang, Wei; de las Fuentes, Lisa et al. (2014) A custom correlation coefficient (CCC) approach for fast identification of multi-SNP association patterns in genome-wide SNPs data. Genet Epidemiol 38:610-21
Victor, Matheus B; Richner, Michelle; Hermanstyne, Tracey O et al. (2014) Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron 84:311-23
Olsen, Brett N; Bielska, Agata A; Lee, Tiffany et al. (2013) The structural basis of cholesterol accessibility in membranes. Biophys J 105:1838-47
Skinner, James R; Harris, Lydia-Ann L S; Shew, Trevor M et al. (2013) Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2:80-6

Showing the most recent 10 out of 83 publications