We are applying to sustain support for years 36 to 40 of The Experimental Pathology of Cardiovascular Disease Training Program (CVP) at the University of Washington's School of Medicine. CVP is an institutional National Research Service Award (NRSA) that has been continuously funded by the NHLBI since 1978. Our proposal builds upon a strong tradition of training independent scientists at both the pre- and postdoctoral levels. Since vascular biology began as a field of cell biology in the early 1970's, CVP has played a major role in this field. Our focus continues to be on the study of heart and blood vessels using innovative tools. Our emphasis today is on stem cell biology, membrane biology, genetics and genomics. CVP continues to focus on innovation by training new independent investigators who benefit from the synergies produced by the extensive interdisciplinary research of our faculty. This collaboration is an important bridge to translate research into applications important to clinical diseases including atherosclerosis, hypertension, and heart failure. Therapeutic opportunities will grow out of our major foci of interest in stem cel biology, regenerative medicine and genetics. This program is the major source of support for basic sciences training in cardiovascular biology and in stem cell biology at the University of Washington and in the Pacific Northwest.

Public Health Relevance

The goal of this T32 program is to attract independent investigators to careers in cardiovascular biology focusing on both basic science and clinical applications in studying diseases related to cardiovascular health. Cardiovascular disease continues to have a growing impact on global health and require innovative techniques to help investigators translate research into clinical applications.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007312-40
Application #
9619365
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Lidman, Karin Fredriksson
Project Start
1978-07-01
Project End
2020-12-31
Budget Start
2019-01-01
Budget End
2020-12-31
Support Year
40
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Powers, Joseph D; Williams, C David; Regnier, Michael et al. (2018) A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics. Integr Comp Biol 58:186-193
Raj, Bushra; Wagner, Daniel E; McKenna, Aaron et al. (2018) Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain. Nat Biotechnol 36:442-450
Hofsteen, Peter; Robitaille, Aaron Mark; Strash, Nicholas et al. (2018) ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience 2:88-100
Lee, Su-In; Celik, Safiye; Logsdon, Benjamin A et al. (2018) A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia. Nat Commun 9:42
Kim, Daniel Seung; Li, Yatong K; Kim, Jerry H et al. (2018) Autosomal dominant mannose-binding lectin deficiency is associated with worse neurodevelopmental outcomes after cardiac surgery in infants. J Thorac Cardiovasc Surg 155:1139-1147.e2
Brewer, Chris M; Majesky, Mark W (2018) Branch Point Smooth Muscle Cells Highlighted by Novel Lineage Tracking Approach. Circ Res 122:194-196
Köksal, Ali Sinan; Beck, Kirsten; Cronin, Dylan R et al. (2018) Synthesizing Signaling Pathways from Temporal Phosphoproteomic Data. Cell Rep 24:3607-3618
McKenna, Aaron; Shendure, Jay (2018) FlashFry: a fast and flexible tool for large-scale CRISPR target design. BMC Biol 16:74
Leonard, Andrea; Bertero, Alessandro; Powers, Joseph D et al. (2018) Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. J Mol Cell Cardiol 118:147-158
Forero, Adriana; So, Lomon; Savan, Ram (2017) Re-evaluating Strategies to Define the Immunoregulatory Roles of miRNAs. Trends Immunol 38:558-566

Showing the most recent 10 out of 185 publications