The Washington University Training Program in Principles of Pulmonary Research provides predoctoral and postdoctoral research training in the disciplines of respiratory cell and molecular biology, genetics, immunology, microbiology, pharmacology, physiology, structural and chemical biology and biochemistry, and developmental biology. The Program emphasizes scientific approaches critical to understanding mechanisms of lung disease with components of fundamental, translational, and clinical research. The postdoctoral portion of the training program enables physicians training in pulmonary and critical care medicine to learn how to perform state-of-the-art scientific research in concert with Ph.D. trainees from a basic science background. In addition, predoctoral trainees in the M.D./Ph.D. and Ph.D. programs in the Division of Biology and Biomedical Sciences are a vital component of the Program.
The aim of the Program is to promote the scientific growth of trainees so they may enter academic pulmonary medicine with the skills needed to study problems relevant to understanding respiratory diseases. The primary and support training faculty consists of 54 full-time members of the Departments of Biostatistics, Biochemistry, Bioengineering, Chemistry, Cell Biology/Physiology, Genetics, Internal Medicine, Molecular Biology/Pharmacology, Microbiology, Pathology/Immunology, Pediatrics, Physics, Radiology, and Surgery. Current research projects span the gamut of respiratory science. The nature of the faculty and the scientific projects ensures a well- organized, multidisciplinary interface of pulmonary researchers with basic scientists. The program is designed to provide trainees with an intensive laboratory or clinical research experience supplemented by graduate coursework and research conferences. In the laboratory, trainees utilize cutting-edge approaches relevant to their particular investigative area. Basic science courses and conferences are used to build skills in evaluating scientific literature, identifying important questions, designing experimental approaches, and organizing, analyzing, and presenting scientific data. Each trainee is under the supervision of a mentor and other supervisory experts as needed for the specific project, and the Program closely monitors trainee and mentor performance. These mechanisms serve to ensure high level trainee experiences in research techniques, lecture presentation, manuscript preparation, grant application, and mentoring.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007317-35
Application #
8293160
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
1978-07-01
Project End
2013-07-31
Budget Start
2012-07-01
Budget End
2013-07-31
Support Year
35
Fiscal Year
2012
Total Cost
$486,236
Indirect Cost
$45,399
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Swiecki, Melissa; Wang, Yaming; Riboldi, Elena et al. (2014) Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells. J Immunol 192:4409-16
Swiecki, Melissa; Wang, Yaming; Gilfillan, Susan et al. (2013) Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infections. PLoS Pathog 9:e1003728
Roumenina, Lubka T; Frimat, Marie; Miller, Elizabeth C et al. (2012) A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood 119:4182-91
Swiecki, Melissa; Wang, Yaming; Gilfillan, Susan et al. (2012) Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection. J Immunol 188:2488-92
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Hajari, A J; Yablonskiy, D A; Sukstanskii, A L et al. (2012) Morphometric changes in the human pulmonary acinus during inflation. J Appl Physiol 112:937-43
Swiecki, Melissa; Wang, Yaming; Vermi, William et al. (2011) Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J Exp Med 208:2367-74
Wang, Yaming; Swiecki, Melissa; McCartney, Stephen A et al. (2011) dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity. Immunol Rev 243:74-90

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