The Washington University Training Program in Principles of Pulmonary Research provides predoctoral and postdoctoral research training in the disciplines of respiratory cell and molecular biology, genetics, immunology, microbiology, pharmacology, physiology, structural and chemical biology and biochemistry, and developmental biology. The Program emphasizes scientific approaches critical to understanding mechanisms of lung disease with components of fundamental, translational, and clinical research. The postdoctoral portion of the training program enables physicians training in pulmonary and critical care medicine to learn how to perform state-of-the-art scientific research in concert with Ph.D. trainees from a basic science background. In addition, predoctoral trainees in the M.D./Ph.D. and Ph.D. programs in the Division of Biology and Biomedical Sciences are a vital component of the Program.
The aim of the Program is to promote the scientific growth of trainees so they may enter academic pulmonary medicine with the skills needed to study problems relevant to understanding respiratory diseases. The primary and support training faculty consists of 54 full-time members of the Departments of Biostatistics, Biochemistry, Bioengineering, Chemistry, Cell Biology/Physiology, Genetics, Internal Medicine, Molecular Biology/Pharmacology, Microbiology, Pathology/Immunology, Pediatrics, Physics, Radiology, and Surgery. Current research projects span the gamut of respiratory science. The nature of the faculty and the scientific projects ensures a well- organized, multidisciplinary interface of pulmonary researchers with basic scientists. The program is designed to provide trainees with an intensive laboratory or clinical research experience supplemented by graduate coursework and research conferences. In the laboratory, trainees utilize cutting-edge approaches relevant to their particular investigative area. Basic science courses and conferences are used to build skills in evaluating scientific literature, identifying important questions, designing experimental approaches, and organizing, analyzing, and presenting scientific data. Each trainee is under the supervision of a mentor and other supervisory experts as needed for the specific project, and the Program closely monitors trainee and mentor performance. These mechanisms serve to ensure high level trainee experiences in research techniques, lecture presentation, manuscript preparation, grant application, and mentoring.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Tigno, Xenia
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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Swiecki, Melissa; Wang, Yaming; Riboldi, Elena et al. (2014) Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells. J Immunol 192:4409-16
Swiecki, Melissa; Wang, Yaming; Gilfillan, Susan et al. (2013) Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infections. PLoS Pathog 9:e1003728
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Swiecki, Melissa; Wang, Yaming; Vermi, William et al. (2011) Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J Exp Med 208:2367-74
Wang, Yaming; Swiecki, Melissa; McCartney, Stephen A et al. (2011) dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity. Immunol Rev 243:74-90

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