This application requests continued funding for a research training program in hematology that has been successful in attracting young physician-scientists into academic medicine. The program has as its primary objective to prepare MD, MD/PhD, and PhD postdoctoral fellows for productive careers as academic scientists and physician-scientists. The focus of training supported by this grant remains within the scientific discipline of hematology. An evolving feature of the training program is an expanded emphasis to provide training opportunities in translational research. The training will be carried out in an enriched environment of active basic and clinical investigation at an institution that emphasizes the career development of physician scientists. The specific objectives are: 1) To identify and recruit outstanding postdoctoral trainees, inclusive of gender and ethnicity, who wish to obtain comprehensive knowledge of the principles and techniques of basic or translational research related to hematology;2) To attract highly motivated clinicians to enter careers as physician-scientists and provide them with comprehensive instruction in the design and implementation of high quality research projects, including participation in cross-disciplinary research teams;3) To train physician-scientists for academic careers in hematology and related scientific disciplines and prepare them for a successful transition to independence;4) To expose talented Ph.D. scientists to the field of hematology and train them for careers as independent investigators. Since the last renewal, the training program has undergone a transition to new leadership and several new initiatives have been instituted. These include a formal external review process, the establishment of a mentoring committee for each trainee, and the implementation of several new strategies to improve the recruitment of trainees from underrepresented minority groups. The rich training environment provided by the diverse faculty, extensive laboratory, clinical, and core facilities, and strong institutional support should ensure continued success in attracting and preparing highly qualified postdoctoral trainees for careers in academic hematology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007344-34
Application #
8307846
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1988-07-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
34
Fiscal Year
2012
Total Cost
$266,646
Indirect Cost
$19,538
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Xu, Xiaojun; Dickey, David D; Chen, Shi-Jie et al. (2016) Structural computational modeling of RNA aptamers. Methods 103:175-9
Dickey, David D; Thomas, Gregory S; Dassie, Justin P et al. (2016) Method for Confirming Cytoplasmic Delivery of RNA Aptamers. Methods Mol Biol 1364:209-17
Vikram, Ajit; Kim, Young-Rae; Kumar, Santosh et al. (2016) Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Nat Commun 7:12565
Gu, C; Yang, Y; Sompallae, R et al. (2016) FOXM1 is a therapeutic target for high-risk multiple myeloma. Leukemia 30:873-82
Thiel, William H; Esposito, Carla L; Dickey, David D et al. (2016) Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. Mol Ther 24:779-87
Rosean, T R; Holman, C J; Tompkins, V S et al. (2016) KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. Blood Cancer J 6:e398
Dickey, David D; Giangrande, Paloma H (2016) Oligonucleotide aptamers: A next-generation technology for the capture and detection of circulating tumor cells. Methods 97:94-103
Tompkins, V S; Rosean, T R; Holman, C J et al. (2016) Adoptive B-cell transfer mouse model of human myeloma. Leukemia 30:962-6
Salem, Kelley; McCormick, Michael L; Wendlandt, Erik et al. (2015) Copper-zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma. Redox Biol 4:23-33
Kelly, Kevin R; Espitia, Claudia M; Zhao, Weiguo et al. (2015) Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus. Oncotarget 6:41275-89

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