This is an application for continued support for the University of Chicago Cardiovascular Sciences Training Program (CTSP). This program is currently in its 29th year of support and provides training in basic and translational cardiovascular sciences to both predoctoral and postdoctoral trainees. This program began in 1970's with the application of molecular techniques to the heart to study ion channel function and mechanisms of cardiac arrhythmias. During the 1980's, molecular biology was introduced into the CSTP. In the 1990's, this program continued in its mission to bring scientific advances to cardiovascular research providing training in murine modeling, including targeted homologous recombination and transgenesis. Coupled with this, our program was one of the first to apply cardiac imaging and phenotyping to murine models of heart disease. In the last five years, we have used our combined expertise at the University of Chicago Biological Sciences Division to draw exceptional trainees to the field of cardiac devlopment and genetics, using the information from the human genome project to understand how individual genes contribute to the normal and abnormal function of the heart. In the next five years, we will build on the strengths of transdisciplinary training at the University of Chicago to investigate genome variation and its relevance to cardiovascular disease. In addition, we will use a systems approach to dissect the networks that are disrupted in heart failure and heart development. The University of Chicago has now created the Institute of Cardiovascular Research to promote interdepartmental efforts and to provide trainees within the CTSP an overarching structure in which they can develop into the next generation of cardiovascular scientists. We train a balance of clinically-skilled MD fellows who wish to pursue careers as physician-scientists, and we train PhD postdoctoral fellows who are directed towards careers in cardiovascular research. Complementing this, we train predoctoral students since this serves to attract young scientists to cardiovascular research early in their career. The mentors in this program derive from ten different departments, all housed on our unified campus and in close proximity. There are four major concentrations within the CSTP and these include: 1) Cardiomyocyte biology, 2) Genetics, Genomics and Systems, 3) Cardiac Development, and 4) Myocyte-vascular Interactions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007381-34
Application #
8286233
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1994-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
34
Fiscal Year
2012
Total Cost
$317,804
Indirect Cost
$31,573
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Addetia, Karima; Yamat, Megan; Mediratta, Anuj et al. (2016) Comprehensive Two-Dimensional Interrogation of the Tricuspid Valve Using Knowledge Derived from Three-Dimensional Echocardiography. J Am Soc Echocardiogr 29:74-82
Waldron, Lauren; Steimle, Jeffrey D; Greco, Todd M et al. (2016) The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell 36:262-75
Burnicka-Turek, Ozanna; Steimle, Jeffrey D; Huang, Wenhui et al. (2016) Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. Hum Mol Genet 25:3011-3028
Mediratta, Anuj; Addetia, Karima; Medvedofsky, Diego et al. (2016) Echocardiographic Diagnosis of Acute Pulmonary Embolism in Patients with McConnell's Sign. Echocardiography 33:696-702
Hernandez, Wenndy; Gamazon, Eric R; Smithberger, Erin et al. (2016) Novel genetic predictors of venous thromboembolism risk in African Americans. Blood 127:1923-9
Hernandez, Wenndy; Aquino-Michaels, Keston; Drozda, Katarzyna et al. (2015) Novel single nucleotide polymorphism in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans. Transl Res 165:651-7
Bovo, Elisa; Mazurek, Stefan R; Fill, Michael et al. (2015) Cytosolic Ca²⁺ buffering determines the intra-SR Ca²⁺ concentration at which cardiac Ca²⁺ sparks terminate. Cell Calcium 58:246-53
Chavez, Jose F; Doll, Jacob A; Mediratta, Anuj et al. (2015) Factors Associated with the Use of Drug-Eluting Stents in Patients Presenting with Acute ST-Segment Elevation Myocardial Infarction. Cardiol Res Pract 2015:528753
Polk, Renita C; Gergics, Peter; Steimle, Jeffrey D et al. (2015) The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. BMC Dev Biol 15:30
Rowton, Megan; Moskowitz, Ivan P (2015) Many ways to break a heart. Elife 4:

Showing the most recent 10 out of 69 publications