The Cardiovascular Sciences Training Program (CSTP) at the University of Chicago provides both pre- doctoral and post-doctoral training. The postdoctoral trainees who participate in the CSTP include both M.D. and Ph.D. trainees. The M.D. trainees are physician scientists most commonly recruited from the Cardiology Fellowship Program at the University of Chicago, and the Ph.D. trainees have received their graduate degrees in diverse areas and seek additional training in the cardiovascular sciences. The CSTP also supports predoctoral training, an element essential to this integrated training program. The postdoctoral training strikes a balance between clinically-trained M.D. fellows who plan careers combining research with clinical medicine, and outstanding Ph.D. fellows who are dedicated to cardiovascular research. The CSTP offers training in six core components: 1) Molecular Cardiology, 2) Genetics/genomics, 3) Development and stem cell biology, 4) Imaging and Translational Biology, 5) Systems Biology, and 6) Vascular &Inflammation. Each of these areas has as its scientific mission furthering our understanding of cardiovascular function in health and disease. To this end, participants in this training program receive didactic, laboratory-based, ethics, and analytic training in order to prepare for careers in cardiovascular research. We propose to continue supporting 3 pre-doctoral and 6 post-doctoral trainees. The range of experience for the post-doctoral trainees ranges from 0 to 6 years of post-doctoral training since M.D. fellows have often completed postgraduate medical training at the time they begin in full time research in the CSTP. In the last training period, we emphasized programs in genetic and genomics reflecting the growth in these fields and their successful application to the cardiovascular sciences. We also enriched training opportunities in regenerative sciences since important advances have been made for cardiac and vascular biology in this area. In this next interval, we have additionally enlisted trainers with accomplishments in systems biology and analysis responding to needs to take better advantage of emerging and existing """"""""big data"""""""" and the expertise on the University of Chicago campus. Systems analysis will be integrated with cardiac genetics and development and regeneration biology, since these topics are critical to define the normal and abnormal function of the heart.

Public Health Relevance

The Cardiovascular Sciences Training Program is dedicated to preparing the next generation of scientists who aim to understand the normal and abnormal function of the heart and vascular system. Heart disease remains a leading killer of Americans and therefore, we need to have investigators who are well trained in cardiac biology. Over this next training period, we have added mentors who are experts in systems analysis to take better advantage of large biomedical data sets that will help us better diagnose and treat cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007381-36A1
Application #
8741287
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
1994-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
36
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60637
Addetia, Karima; Yamat, Megan; Mediratta, Anuj et al. (2016) Comprehensive Two-Dimensional Interrogation of the Tricuspid Valve Using Knowledge Derived from Three-Dimensional Echocardiography. J Am Soc Echocardiogr 29:74-82
Waldron, Lauren; Steimle, Jeffrey D; Greco, Todd M et al. (2016) The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell 36:262-75
Burnicka-Turek, Ozanna; Steimle, Jeffrey D; Huang, Wenhui et al. (2016) Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. Hum Mol Genet 25:3011-3028
Mediratta, Anuj; Addetia, Karima; Medvedofsky, Diego et al. (2016) Echocardiographic Diagnosis of Acute Pulmonary Embolism in Patients with McConnell's Sign. Echocardiography 33:696-702
Hernandez, Wenndy; Gamazon, Eric R; Smithberger, Erin et al. (2016) Novel genetic predictors of venous thromboembolism risk in African Americans. Blood 127:1923-9
Hernandez, Wenndy; Aquino-Michaels, Keston; Drozda, Katarzyna et al. (2015) Novel single nucleotide polymorphism in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans. Transl Res 165:651-7
Bovo, Elisa; Mazurek, Stefan R; Fill, Michael et al. (2015) Cytosolic Ca²⁺ buffering determines the intra-SR Ca²⁺ concentration at which cardiac Ca²⁺ sparks terminate. Cell Calcium 58:246-53
Chavez, Jose F; Doll, Jacob A; Mediratta, Anuj et al. (2015) Factors Associated with the Use of Drug-Eluting Stents in Patients Presenting with Acute ST-Segment Elevation Myocardial Infarction. Cardiol Res Pract 2015:528753
Polk, Renita C; Gergics, Peter; Steimle, Jeffrey D et al. (2015) The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. BMC Dev Biol 15:30
Rowton, Megan; Moskowitz, Ivan P (2015) Many ways to break a heart. Elife 4:

Showing the most recent 10 out of 69 publications