The Cardiovascular Sciences Training Program (CSTP) at the University of Chicago provides both pre- doctoral and post-doctoral training. The postdoctoral trainees who participate in the CSTP include both M.D. and Ph.D. trainees. The M.D. trainees are physician scientists most commonly recruited from the Cardiology Fellowship Program at the University of Chicago, and the Ph.D. trainees have received their graduate degrees in diverse areas and seek additional training in the cardiovascular sciences. The CSTP also supports predoctoral training, an element essential to this integrated training program. The postdoctoral training strikes a balance between clinically-trained M.D. fellows who plan careers combining research with clinical medicine, and outstanding Ph.D. fellows who are dedicated to cardiovascular research. The CSTP offers training in six core components: 1) Molecular Cardiology, 2) Genetics/genomics, 3) Development and stem cell biology, 4) Imaging and Translational Biology, 5) Systems Biology, and 6) Vascular & Inflammation. Each of these areas has as its scientific mission furthering our understanding of cardiovascular function in health and disease. To this end, participants in this training program receive didactic, laboratory-based, ethics, and analytic training in order to prepare for careers in cardiovascular research. We propose to continue supporting 3 pre-doctoral and 6 post-doctoral trainees. The range of experience for the post-doctoral trainees ranges from 0 to 6 years of post-doctoral training since M.D. fellows have often completed postgraduate medical training at the time they begin in full time research in the CSTP. In the last training period, we emphasized programs in genetic and genomics reflecting the growth in these fields and their successful application to the cardiovascular sciences. We also enriched training opportunities in regenerative sciences since important advances have been made for cardiac and vascular biology in this area. In this next interval, we have additionally enlisted trainers with accomplishments in systems biology and analysis responding to needs to take better advantage of emerging and existing big data and the expertise on the University of Chicago campus. Systems analysis will be integrated with cardiac genetics and development and regeneration biology, since these topics are critical to define the normal and abnormal function of the heart.

Public Health Relevance

The Cardiovascular Sciences Training Program is dedicated to preparing the next generation of scientists who aim to understand the normal and abnormal function of the heart and vascular system. Heart disease remains a leading killer of Americans and therefore, we need to have investigators who are well trained in cardiac biology. Over this next training period, we have added mentors who are experts in systems analysis to take better advantage of large biomedical data sets that will help us better diagnose and treat cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007381-37
Application #
8835127
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
1994-07-01
Project End
2019-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
37
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Imamura, Teruhiko; Kim, Gene; Raikhelkar, Jayant et al. (2018) Decoupling Between Diastolic Pulmonary Arterial Pressure and Pulmonary Arterial Wedge Pressure at Incremental Left Ventricular Assist Device (LVAD) Speeds Is Associated With Worse Prognosis After LVAD Implantation. J Card Fail 24:575-582
Imamura, Teruhiko; Nguyen, Ann; Rodgers, Daniel et al. (2018) Omega-3 Therapy Is Associated With Reduced Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Device. Circ Heart Fail 11:e005082
Holzhauser, Luise; Nguyen, Ann; Jeevanandam, Valluvan et al. (2018) HeartNetâ„¢ in an explanted heart of a Jehovah's Witness. J Card Surg 33:765
Laffin, Luke J; Hofmann-Bowman, Marion A (2018) Beyond Hypertension and Cardio-Renal Syndrome: The Need to Acknowledge and Incorporate Renal Disease in Cardiac Electrophysiology Trials. Am J Nephrol 48:32-35
Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:
Juricek, Colleen; Imamura, Teruhiko; Nguyen, Ann et al. (2018) Long-Acting Octreotide Reduces the Recurrence of Gastrointestinal Bleeding in Patients With a Continuous-Flow Left Ventricular Assist Device. J Card Fail 24:249-254
Tehrani, David M; Adatya, Sirtaz; Grinstein, Jonathan et al. (2018) Impact of Cardiac Resynchronization Therapy on Left Ventricular Unloading in Patients with Implanted Left Ventricular Assist Devices. ASAIO J :
Grinstein, Jonathan; Rodgers, Daniel; Kalantari, Sara et al. (2018) HVAD Waveform Analysis as a Noninvasive Marker of Pulmonary Capillary Wedge Pressure: A First Step Toward the Development of a Smart Left Ventricular Assist Device Pump. ASAIO J 64:10-15
Narang, Akhil; Mor-Avi, Victor; Prado, Aldo et al. (2018) Machine learning based automated dynamic quantification of left heart chamber volumes. Eur Heart J Cardiovasc Imaging :
Grinstein, Jonathan; Kruse, Eric; Sayer, Gabriel et al. (2018) Outflow Cannula Systolic Slope in Patients With Left Ventricular Assist Devices: A Novel Marker of Myocardial Contractility. ASAIO J :

Showing the most recent 10 out of 164 publications