The Hematology Research Training Program at the University of Pennsylvania was established in 1978 and has provided training for 111 basic, translation and patient-oriented investigators. Since 2004 the program and this T32 have supported 8 postdoctoral and 4 predoctoral trainees per year. The continuing goal of the program is to help individuals interested in the broadly-defined disciplines of hematology prepare for careers as independent investigators. Originally the candidates were drawn almost exclusively from physicians enrolled in the clinical hematology training programs in the Departments of Medicine and Pediatrics. Since 1998 we have included non-physician postdoctoral trainees and since 2004 we have also incorporated predoctoral trainees, with an emphasis on future physician-scientists in Penn's MD-PhD program to take advantage of the Pi's role as the director of that program. The addition of predoctoral MD-PhD and PhD students to the program reflects our belief in the long term value of attracting talented students in hematology-related research at an earlier point in their training as scientists and physician-scientists. Starting in 2006, PhD candidates at Penn, including those in this program, have also had the option of enrolling in the Graduate Training in Medical Sciences (GTMS) Certificate Program, expanding their opportunities for cross training in human biology and disease. Outcomes. During the first 29 years of funding, 103 postdoctoral trainees (66 MD, 13 MD-PhD and 24 PhD) and 8 pre-doctoral trainee (6 MD-PhD and 2 PhD) have been supported. Of the 90 postdoctoral trainees who have completed training, 61% hold full-time appointments at an academic institution and are engaged in either laboratory or clinical research. An additional 9% are engaged primarily in clinical practice, but have university appointments and participate in clinical research projects and teaching part-time. 53% of our former trainees who have completed training have extramural research funding from the NIH and other sources, 11% have positions in industry and 4% are completing further postdoctoral studies. A detailed plan for identifying appropriate predoctoral and postdoctoral candidates, providing them with the skills needed for an independent career, and mentoring them throughout the process is included in the application.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Tomaiuolo, Maurizio; Stalker, Timothy J; Welsh, John D et al. (2014) A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood 124:1816-23
Thom, Christopher S; Traxler, Elizabeth A; Khandros, Eugene et al. (2014) Trim58 degrades Dynein and regulates terminal erythropoiesis. Dev Cell 30:688-700
Babushok, Daria; Hexner, Elizabeth (2014) Allogeneic transplantation for myelofibrosis: for whom, when, and what are the true benefits? Curr Opin Hematol 21:114-22
Welsh, John D; Stalker, Timothy J; Voronov, Roman et al. (2014) A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood 124:1808-15
Stalker, Timothy J; Welsh, John D; Tomaiuolo, Maurizio et al. (2014) A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood 124:1824-31
Colace, T V; Fogarty, P F; Panckeri, K A et al. (2014) Microfluidic assay of hemophilic blood clotting: distinct deficits in platelet and fibrin deposition at low factor levels. J Thromb Haemost 12:147-58
Stalker, Timothy J; Welsh, John D; Brass, Lawrence F (2014) Shaping the platelet response to vascular injury. Curr Opin Hematol 21:410-7
Babushok, Daria V; Xie, Hongbo M; Roth, Jacquelyn J et al. (2014) Single nucleotide polymorphism array analysis of bone marrow failure patients reveals characteristic patterns of genetic changes. Br J Haematol 164:73-82
Howard, Melissa D; Greineder, Colin F; Hood, Elizabeth D et al. (2014) Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation. J Control Release 177:34-41
Min, Sang H; Suzuki, Aae; Stalker, Timothy J et al. (2014) Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nat Commun 5:4691

Showing the most recent 10 out of 66 publications