This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, MD, PD/PI, offers postdoctoral training in fundamental aspects of the pathophysiology of hypertension and cardiovascular (CV) diseases and in innovative approaches to the treatment of these conditions. The Program has recently been enriched to include new training opportunities in free radical biology, vascular inflammation, atherogenesis, matrix biology, obesity/metabolism, statistical genetics and genomics, cardiac remodeling/ failure, and arrhythmogenesis, as well as clinical and translational research in chronic kidney disease, diabetes/metabolism and resistant hypertension. The UAB CCTS offers advanced training in quantitative sciences, including bioinformatics, systems biology and computational techniques, that will augment our existing Program and equip trainees to function in these important new research areas. The UAB Office for Postdoctoral Education (OPE) offers our trainees valuable guidance and instruction in survival skills, including counseling re-career opportunities in academia and the biotechnology/pharmaceutical industry. Our multidisciplinary faculty has expertise in molecular and cell biology, physiology, biostatistics, and clinical and translational research. Training opportunities are available in four Thematic Groups: Vascular injury/inflammation/ atherogenesis;oxidative stress/free radical injury;cardiac remodeling/failure, and clinical/ translational research. Each trainee is given in-depth experience in one area of research and will be exposed to other areas through seminars, conferences, and course work. Trainees will have a concentrated 2- 3 year experience in laboratory or clinical/translational research under the direction of mentors from the training faculty. Trainees will spend at least 80% of time in investigation, in taking relevant courses, and in attending scientific meetings. The goal of this Program is to prepare trainees for careers in both fundamental and clinical/translational research in CV disease. The educational experiences available to our trainees are sufficient to equip graduates of the Program with the appropriate technical skills and theoretical background to make them competitive for faculty positions in prestigious academic institutions through the country or in the biotechnology/pharmaceutical industry. Relevance: There is a shortage of basic, translational and clinical scientists who are trained to use cutting edge approaches to problems related to hypertension and cardiovascular disease, a leading cause of death and disability in the US. Ours is the only Program in Alabama that provides highly integrated "bench to bedside" training in cardiovascular science for MD- and PhD-prepared trainees.

Public Health Relevance

This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, MD, PD/PI, offers postdoctoral training in fundamental aspects of the pathophysiology of hypertension and cardiovascular diseases and in innovative approaches to the treatment of these conditions. Training opportunities are available in four Thematic Groups: Vascular injury/inflammation/ atherogenesis; oxidative stress/free radical injury;cardiac remodeling/failure, and clinical/ translational research. The educational experiences available to our trainees are sufficient to equip graduates of the Program with the appropriate technical skills and theoretical background to make them competitive for faculty positions in prestigious academic institutions through the country or in the biotechnology/pharmaceutical industry.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007457-33
Application #
8494655
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1980-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
33
Fiscal Year
2013
Total Cost
$365,771
Indirect Cost
$26,597
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Lewis, Dwight W; Dutton, Gareth R; Affuso, Olivia (2015) Physical characteristics associated with weight misperception among overweight and obese men: NHANES 1999-2006. Obesity (Silver Spring) 23:242-7
Scott, David W; Black, Leland L; Vallejo, Matthew O et al. (2014) Increased sensitivity of Apolipoprotein E knockout mice to swainsonine dependent immunomodulation. Immunobiology 219:497-502
Honavar, Jaideep; Bradley, Eddie; Bradley, Kelley et al. (2014) Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature. Toxicology 321:96-102
Judd, E; Calhoun, D A (2014) Apparent and true resistant hypertension: definition, prevalence and outcomes. J Hum Hypertens 28:463-8
Affuso, O; Kaiser, K A; Carson, T L et al. (2014) Association of run-in periods with weight loss in obesity randomized controlled trials. Obes Rev 15:68-73
Lewis Jr, Dwight W (2014) Are the results likely biased toward the null? Obesity (Silver Spring) 22:2326
Kent, Shia T; Shimbo, Daichi; Huang, Lei et al. (2014) Antihypertensive medication classes used among medicare beneficiaries initiating treatment in 2007-2010. PLoS One 9:e105888
Ravi, Saranya; Mitchell, Tanecia; Kramer, Philip A et al. (2014) Mitochondria in monocytes and macrophages-implications for translational and basic research. Int J Biochem Cell Biol 53:202-7
Kramer, Philip A; Chacko, Balu K; Ravi, Saranya et al. (2014) Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets. J Vis Exp :
Kent, Shia T; Shimbo, Daichi; Huang, Lei et al. (2014) Rates, amounts, and determinants of ambulatory blood pressure monitoring claim reimbursements among Medicare beneficiaries. J Am Soc Hypertens 8:898-908

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