Hematology, the study of normal and diseased blood elements and their interaction with the vasculature in which they reside, is a fertile research field, in no small part due to the enviable access of hematologic researchers to primary tissues. Nonetheless, despite remarkable breakthroughs in our understanding of the molecular basis for a wide variety of hematologic illnesses, there remains a gap between our current knowledge and our ability to substantively alter the course of these diseases. The goals of the BUSM Hematology Training Program (HTP) are to attract talented researchers to a hematologic research project, to inspire them to choose some aspect of hematology for their subsequent research careers, and to give them the knowledge base, the technical skills and the grant-writing ability to be able to establish themselves as independent researchers in an academic setting. Our proposed training program, which has been existence since 1980, will train four pre-doctoral students and four post-doctoral students, the latter with either PhD (2) or MD (2) degrees. Trainees will be mentored by a select group of 18 faculty whose research interests are particularly strong in the following four areas: Hemoglobinopathies, Immunotherapy and Immunopathology, Lymphoid Cell Signaling and Gene Expression, and Platelet and Thrombosis Biology. Pre-doctoral students enrolled in established basic science programs such as Biochemistry, Microbiology or Molecular Medicine typically apply to the HTP executive committee during their second year of graduate school. Both pre-doctoral students and post- doctoral fellows attend Hematology Journal Club, Hematology Grand Rounds and a Molecules to Molecular Therapeutics course which is an in depth study of hemoglobinopathies. By fostering an atmosphere in which clinicians and basic science researchers work in close collaboration, our program will train the next generation of hematology researchers to identify practical therapeutic approaches that will close the gap between our knowledge of the molecular basis for hematologic illness and its successful treatment.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007501-31
Application #
8319418
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1980-07-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
31
Fiscal Year
2012
Total Cost
$314,738
Indirect Cost
$26,081
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Peskin, Alexander V; Pace, Paul E; Behring, Jessica B et al. (2016) Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin. J Biol Chem 291:3053-62
Anderson, N M; Li, D; Peng, H L et al. (2016) The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia 30:1365-74
Ip, Blanche; Cilfone, Nicholas A; Belkina, Anna C et al. (2016) Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production. Obesity (Silver Spring) 24:102-12
Harrold, Itrat; Carbonneau, Seth; Moore, Bethany M et al. (2016) Efficient transgenesis mediated by pigmentation rescue in zebrafish. Biotechniques 60:13-20
Haery, Leila; Mussakhan, Sultan; Waxman, David J et al. (2016) Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma. Leuk Lymphoma 57:2661-71
Bader, Hannah L; Hsu, Tien (2016) Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model. BMC Cancer 16:797
Vathipadiekal, Vinod; Alsultan, Abdulrahman; Baltrusaitis, Kristin et al. (2016) Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia. Am J Hematol 91:E308-11
Vathipadiekal, Vinod; Farrell, John J; Wang, Shuai et al. (2016) A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol 91:1118-1122
Shivanna, Sowmya; Harrold, Itrat; Shashar, Moshe et al. (2015) The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. J Biol Chem 290:12537-46
dos Santos, Gimena; Rogel, Micah R; Baker, Margaret A et al. (2015) Vimentin regulates activation of the NLRP3 inflammasome. Nat Commun 6:6574

Showing the most recent 10 out of 92 publications