The Boston University-Boston Medical Center Training Program in Blood Diseases and Resources"""""""" (HTP) is a training program in hematology research that has been active at Boston University Medical Center since 1980, currently supporting four pre-doctoral and four post-doctoral trainees/year. The objective of this training program is to provide training in hematology research to graduate students and PhD, MD, or MD PhD post- doctoral trainees who work with any of 21 HTP faculty. Our program faculty carry out hematology-related research in four areas: Hemoglobinopathies, Platelet and Thrombosis Biology, Hematopoiesis, and Lymphoid Cell Signaling and Immunopathology. BU and BUSM offer a rich research environment for trainees interested in hematology-related basic science, translational or clinical research projects. Among the research resources available to HTP trainees are the Boston University Center of Excellence in Sickle Cell Disease, the BUSM Center for Regenerative Medicine and the BUSM Amyloidosis Center. One of the strengths of the program is regular interaction at weekly Journal Clubs and Work Seminars between HTP-supported doctoral students, post-doctoral (PhD) fellows and physicians carrying out their hematology fellowships. At the weekly Hematology Grand Rounds, talks are given by outside hematology researchers and such experts are made available to meet with HTP trainees. Doctoral students enter the HTP after having matriculated in variety of BU or BUSM doctoral programs, including Biochemistry, Biology, Biostatistics, Microbiology, Molecular Medicine, Pathology and Pharmacology. A new clinical research track is now offered to physicians who wish to obtain training in hematology-related clinical research.

Public Health Relevance

The Boston University-Boston Medical Center Training Program in Blood Diseases and Resources (HTP) is a training program in hematology research that has been active at Boston University Medical Center since 1980, currently supporting four pre-doctoral and four post-doctoral trainees/year. Hematology encompasses normal and abnormal blood biology, including the biology of red blood cells, white blood cells and platelets, as well as the related fields of normal and abnormal blood clotting and blood cell development in the bone marrow. Providing the next generation of PhDs, MDs and MD PhDs who have an interest in hematology research with appropriate training in this complex field is an important element in guaranteeing continued progress in the treatment of blood-related diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007501-32
Application #
8607727
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1980-07-01
Project End
2019-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
32
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02118
Sewell, Jared A; Fuxman Bass, Juan I (2017) Cellular network perturbations by disease-associated variants. Curr Opin Syst Biol 3:60-66
Nicholas, Dequina A; Andrieu, Guillaume; Strissel, Katherine J et al. (2017) BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci 74:231-243
Shao, Di; Han, Jingyan; Hou, Xiuyun et al. (2017) Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal :
Shaikho, Elmutaz M; Farrell, John J; Alsultan, Abdulrahman et al. (2017) A phased SNP-based classification of sickle cell anemia HBB haplotypes. BMC Genomics 18:608
Kato, Gregory J; Steinberg, Martin H; Gladwin, Mark T (2017) Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest 127:750-760
Habara, Alawi H; Shaikho, Elmutaz M; Steinberg, Martin H (2017) Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents. Am J Hematol 92:1233-1242
Lian, Haiwei; Li, Dun; Zhou, Yun et al. (2017) CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica 102:e17-e21
Morrison, Tasha A; Wilcox, Ibifiri; Luo, Hong-Yuan et al. (2017) A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression. Blood Cells Mol Dis 69:1-9
Shaikho, Elmutaz M; Farrell, John J; Alsultan, Abdulrahman et al. (2017) Genetic determinants of HbF in Saudi Arabian and African Benin haplotype sickle cell anemia. Am J Hematol 92:E555-E557
Aleluia, Milena Magalhães; Santiago, Rayra Pereira; da Guarda, Caroline Conceição et al. (2017) Genetic modulation of fetal hemoglobin in hydroxyurea-treated sickle cell anemia. Am J Hematol 92:E70-E72

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