This competing revised renewal application for continued support of an NHLBI (Lung Division) Post-Doctoral Training Grant, which is currently in its 30th year in the University of Michigan Medical School, Department of Pathology.
The aim of this program is to provide in-depth training in basic research to individuals that have successfully completed MD, PhD, or DVM degrees. The research areas of focus include lung inflammation (mediators and regulators), complement, apoptosis, DNA repair, epigenetics, immunopathology (including the roles of oxidants, proteases, cytokines, and chemokines), and cell biology. The pathogenesis of a number of pulmonary diseases are emphasized in our training program such as sepsis (ARDS), fibrosis, and asthma. Since inception, the program was originally led by Professor Peter A. Ward for 25 years. Dr. Nicholas Lukacs took over as director in the previous training grant cycle, from year 26-30. This experimental pathology program has extended to strong investigators in other departments throughout the University of Michigan Medical Center, including Pediatric pulmonary, adult pulmonary and Microbiology/Immunology. In this renewal we have further expanded the scope, adding not only new faculty trainers, but also the scientific expertise that will allow our program to examine epigenetic control of the inflammatory and pathogenic responses during lung disease. This expansion will serve to strengthen and enhance the training program. Trainees are able to interact easily between laboratories due to the close collaborative interactions between preceptors, further enhancing collaborative and training experiences. This program has had the distinction of training an impressive number of post-doctoral researchers, M.D. and Ph.D. that have gone onto strong academic and research careers. Over the past 10 years of the program we have had success recruiting outstanding trainees whom have gone onto academic careers. The setting of this program in the context of a large and diverse academic medical center provides special advantages to trainees related to relevant research endeavors of the preceptors that are closely linked to clinical disease. This latter aspect of translational researc effort in the Department of Pathology is central to the efforts at the Medical School. Thus, this T32 has a proven record of training researchers and will continue to successfully train post-doctoral fellows in research related to lung diseases that affect large numbers of patients.
The Immunopathology of Pulmonary Diseases (IoPD) T32 Training program has been in existence for 30 years and has maintained a high standard of Trainee requirements and expectations for development. Our overall goals are to provide an intense and rigorous training program in basic and applied mechanisms of Pulmonary Disease for post-doctoral researchers that will prepare them for a future career as an independent Academic researcher.
|Grailer, Jamison J; Fattahi, Fatemeh; Dick, Rachel S et al. (2015) Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice. J Immunol 194:868-72|
|Grailer, Jamison J; Kalbitz, Miriam; Zetoune, Firas S et al. (2014) Persistent neutrophil dysfunction and suppression of acute lung injury in mice following cecal ligation and puncture sepsis. J Innate Immun 6:695-705|
|Grailer, Jamison J; Haggadone, Mikel D; Sarma, J Vidya et al. (2014) Induction of M2 regulatory macrophages through the ?2-adrenergic receptor with protection during endotoxemia and acute lung injury. J Innate Immun 6:607-18|
|Werner, Jessica L; Steele, Chad (2014) Innate receptors and cellular defense against pulmonary infections. J Immunol 193:3842-50|
|Grailer, Jamison J; Canning, Bethany A; Kalbitz, Miriam et al. (2014) Critical role for the NLRP3 inflammasome during acute lung injury. J Immunol 192:5974-83|
|Kenneth, Niall S; Younger, J Michael; Hughes, Elizabeth D et al. (2012) An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J 443:355-9|
|Franchi, Luigi; Kamada, Nobuhiko; Nakamura, Yuumi et al. (2012) NLRC4-driven production of IL-1* discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol 13:449-56|
|Bosmann, Markus; Grailer, Jamison J; Zhu, Ketong et al. (2012) Anti-inflammatory effects of ?2 adrenergic receptor agonists in experimental acute lung injury. FASEB J 26:2137-44|
|Shaw, Michael H; Kamada, Nobuhiko; Kim, Yun-Gi et al. (2012) Microbiota-induced IL-1ýý, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine. J Exp Med 209:251-8|
|Kim, Yun-Gi; Shaw, Michael H; Warner, Neil et al. (2011) Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. J Immunol 187:2849-52|
Showing the most recent 10 out of 63 publications