This competing revised renewal application for continued support of an NHLBI (Lung Division) Post-Doctoral Training Grant, which is currently in its 30th year in the University of Michigan Medical School, Department of Pathology.
The aim of this program is to provide in-depth training in basic research to individuals that have successfully completed MD, PhD, or DVM degrees. The research areas of focus include lung inflammation (mediators and regulators), complement, apoptosis, DNA repair, epigenetics, immunopathology (including the roles of oxidants, proteases, cytokines, and chemokines), and cell biology. The pathogenesis of a number of pulmonary diseases are emphasized in our training program such as sepsis (ARDS), fibrosis, and asthma. Since inception, the program was originally led by Professor Peter A. Ward for 25 years. Dr. Nicholas Lukacs took over as director in the previous training grant cycle, from year 26-30. This experimental pathology program has extended to strong investigators in other departments throughout the University of Michigan Medical Center, including Pediatric pulmonary, adult pulmonary and Microbiology/Immunology. In this renewal we have further expanded the scope, adding not only new faculty trainers, but also the scientific expertise that will allow our program to examine epigenetic control of the inflammatory and pathogenic responses during lung disease. This expansion will serve to strengthen and enhance the training program. Trainees are able to interact easily between laboratories due to the close collaborative interactions between preceptors, further enhancing collaborative and training experiences. This program has had the distinction of training an impressive number of post-doctoral researchers, M.D. and Ph.D. that have gone onto strong academic and research careers. Over the past 10 years of the program we have had success recruiting outstanding trainees whom have gone onto academic careers. The setting of this program in the context of a large and diverse academic medical center provides special advantages to trainees related to relevant research endeavors of the preceptors that are closely linked to clinical disease. This latter aspect of translational researc effort in the Department of Pathology is central to the efforts at the Medical School. Thus, this T32 has a proven record of training researchers and will continue to successfully train post-doctoral fellows in research related to lung diseases that affect large numbers of patients.
The Immunopathology of Pulmonary Diseases (IoPD) T32 Training program has been in existence for 30 years and has maintained a high standard of Trainee requirements and expectations for development. Our overall goals are to provide an intense and rigorous training program in basic and applied mechanisms of Pulmonary Disease for post-doctoral researchers that will prepare them for a future career as an independent Academic researcher.
|Werner, Jessica L; Escolero, Sylvia G; Hewlett, Jeff T et al. (2017) Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2. Am J Respir Cell Mol Biol 56:121-130|
|Pickard, Joseph M; Zeng, Melody Y; Caruso, Roberta et al. (2017) Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunol Rev 279:70-89|
|He, Yuan; Zeng, Melody Y; Yang, Dahai et al. (2016) NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530:354-7|
|Bermick, Jennifer R; Lambrecht, Nathalie J; denDekker, Aaron D et al. (2016) Neonatal monocytes exhibit a unique histone modification landscape. Clin Epigenetics 8:99|
|Habiel, David M; Krepostman, Nicolas; Lilly, Michael et al. (2016) Senescent stromal cell-induced divergence and therapeutic resistance in T cell acute lymphoblastic leukemia/lymphoma. Oncotarget 7:83514-83529|
|Kalbitz, Miriam; Fattahi, Fatemeh; Herron, Todd J et al. (2016) Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro. J Immunol 197:2353-61|
|He, Yuan; Hara, Hideki; Núñez, Gabriel (2016) Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends Biochem Sci 41:1012-1021|
|Xu, Jing; Li, Li; Xiong, Jie et al. (2016) MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program. Cell Discov 2:16008|
|Zeng, Melody Y; Cisalpino, Daniel; Varadarajan, Saranyaraajan et al. (2016) Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity 44:647-658|
|Kalbitz, Miriam; Fattahi, Fatemeh; Grailer, Jamison J et al. (2016) Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis. FASEB J 30:3997-4006|
Showing the most recent 10 out of 89 publications