The primary objective of the Training Program in Hematology, which will complete its 30th year of funding in 2014, is to train MD, MD/PhD, and PhD postdoctoral fellows interested in adult hematology for careers in academic medicine and biomedical research. Johns Hopkins hematology fellows, the major substrate for this T32, rotate on benign and malignant hematology services but do not rotate on any solid tumor rotations. Thus, the purpose of the proposed training program is to prepare qualified individuals with an MD and/or PhD degree for a research career in the field of adult hematology. The training program consists of well-funded and highly experienced investigators, most of who are internationally recognized for their research pertaining to hematopoiesis and stem cell biology, anemias, vascular biology, bone marrow failure states and myeloproliferative diseases. Training is enhanced by an outstanding research environment with state-of-the-art research facilities, outstanding faculty mentors, and existing program project grants on bone marrow transplantation and stem cell biology. Despite a national trend away from single board hematology fellowship programs, Johns Hopkins continues to attract outstanding MD and MD/PhD candidate for single board hematology training and prepares them for careers in biomedical research.
Specific aims are of this training program are: 1) to provide research training opportunities in a variety of areas pertaining to hematology including benign and malignant hematopoiesis, bone marrow failure disorders, bone marrow transplantation, stem cell biology, immunology, genetics, vascular biology, and myeloproliferative/myelodysplastic syndromes 2) to provide the opportunity for structured coursework and seminars pertaining to clinical, translational and basic research pertaining to hematology, and to provide opportunities for instruction in grant writing, manuscript writing, public speaking and biostatistics 3) to allo for group mentoring and careful monitoring of the trainees'progress and the overall success of the training program 4) to address the critical shortage of adult hematologists in pursuing careers in academic hematology

Public Health Relevance

The goal of this Program is to attract and to train exceptional postdoctoral fellows for careers in academic adult hematology. Improved understanding of the underpinnings of stem cell biology, anemias, vascular biology, bone marrow failure states, and myeloproliferative diseases will aid in translating laboratory findings into novel clinical therapies.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007525-31
Application #
8607718
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1982-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Gocke, Christian B; McMillan, Ross; Wang, Qiuju et al. (2016) IQGAP1 Scaffold-MAP Kinase Interactions Enhance Multiple Myeloma Clonogenic Growth and Self-Renewal. Mol Cancer Ther 15:2733-2739
McDonnell, Megan H; Smith Jr, Elton T; Lipford, Edward H et al. (2016) Microgranular acute promyelocytic leukemia presenting with leukopenia and an unusual immunophenotype. Hematol Oncol Stem Cell Ther :
Gerber, Jonathan M; Zeidner, Joshua F; Morse, Sarah et al. (2016) Association of acute myeloid leukemia's most immature phenotype with risk groups and outcomes. Haematologica 101:607-16
Lombardi, Lindsey R; Kanakry, Christopher G; Zahurak, Marianna et al. (2016) Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre- and post-transplantation cyclophosphamide. Leuk Lymphoma 57:666-75
Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui (2016) Genome editing systems in novel therapies. Discov Med 21:57-64
Vaught, Arthur J; Gavriilaki, Eleni; Hueppchen, Nancy et al. (2016) Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome. Exp Hematol 44:390-8
Kanakry, Jennifer A; Gocke, Christopher D; Bolaños-Meade, Javier et al. (2015) Phase II Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation for B Cell Lymphoma with Post-Transplantation Rituximab and Donor Selection Based First on Non-HLA Factors. Biol Blood Marrow Transplant 21:2115-22
Alonso, Salvador; Su, Meng; Jones, Jace W et al. (2015) Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes. Oncotarget 6:14905-12
Lim, Yiting; Gondek, Lukasz; Li, Li et al. (2015) Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med 7:291ra96
Churpek, Jane E; Pyrtel, Khateriaa; Kanchi, Krishna-Latha et al. (2015) Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood 126:2484-90

Showing the most recent 10 out of 107 publications