This program will provide predoctoral and postdoctoral training to produce future independent investigators with multidisciplinary experiences that span several basic mission areas of the NHLBI (sleep and hypoxic response, cardiopulmonary and cardio-renal diseases, hypertension, and inflammation/infection), but is rooted in rigorous biostatistical, epidemiologic, genetic/genomic and computational approaches to problem solving. After providing only postdoctoral training for the first fifteen years, the program was expanded in 1999 to provide both predoctoral and postdoctoral training and will continue to provide both types of training. Predoctoral training will be for the Ph.D. degree in Epidemiology and Biostatistics through the Division of Genetic and Molecular Epidemiology, with the trainees gaining general expertise in population sciences, particularly in solving problems related to "omics" in large samples through the development of innovative modeling strategies. This will be done with the help of a mentoring committee that will ensure the student receives sound training in statistical genetics as well as exposure to collaborations with the broader Case Community in other departments and Centers of Excellence that have relevant clinical and basic science expertise. The most important mode of training for postdoctoral students will be that of conducting collaborative research with faculty: methodological research (using mathematical derivations or computer simulations) and/or substantive research by means of data analysis. It is anticipated that half the postdoctoral students will already have had training in a cardiopulmonary area but, in order to gain the necessary epidemiological/statistical expertise, will need to formally register for the MS degree in Epidemiology and Biostatistics. All trainees, both pre- and post-doctoral, will attend regularly scheduled seminars and specific lecture and/or reading courses, including mandatory lectures in bioethics. Particular features of the program will be;computational laboratory cross-training, short-term training stints in basic science laboratories, interaction with the Medical Scientist Training Program, and the presence of internationally known biostatisticians/geneticists/genetic epidemiologists as visitors, for periods of one to several days, giving seminars and short courses in their particular fields of specialty and talking to the trainees about their research projects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007567-30
Application #
8508999
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Silsbee, Lorraine M
Project Start
1994-07-01
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
30
Fiscal Year
2013
Total Cost
$374,228
Indirect Cost
$23,412
Name
Case Western Reserve University
Department
Genetics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Di, Xiao-Jing; Wang, Ya-Juan; Han, Dong-Yun et al. (2016) Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation. J Biol Chem 291:9526-39
Liang, Jingjing; Cade, Brian E; Wang, Heming et al. (2016) Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses. Genet Epidemiol 40:222-32
Fluegge, Kyle (2016) The new frontier in health services research: a behavioural paradigm guided by genetics. J Health Serv Res Policy :
Fluegge, Kyle (2016) Benefit of treatment of latent tuberculosis infection in individual patients. Eur Respir J 47:1592-4
Fluegge, Kyle R (2016) Comorbidities Among Persons With Incident Psychiatric Condition. Gerontol Geriatr Med 2:
Brubaker, Douglas; Barbaro, Alethea; R Chance, Mark et al. (2016) A dynamical systems model of progesterone receptor interactions with inflammation in human parturition. BMC Syst Biol 10:79
Sobota, Rafal S; Stein, Catherine M; Kodaman, Nuri et al. (2016) A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals. Am J Hum Genet 98:514-24
Fluegge, Kyle (2016) Community water fluoridation predicts increase in age-adjusted incidence and prevalence of diabetes in 22 states from 2005 and 2010. J Water Health 14:864-877
Fluegge, Keith R; Fluegge, Kyle R (2015) Glyphosate Use Predicts ADHD Hospital Discharges in the Healthcare Cost and Utilization Project Net (HCUPnet): A Two-Way Fixed-Effects Analysis. PLoS One 10:e0133525
Hall, N B; Igo Jr, R P; Malone, L L et al. (2015) Polymorphisms in TICAM2 and IL1B are associated with TB. Genes Immun 16:127-33

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