Cardiovascular disease is the leading cause of death in the United States. There is an ongoing need to provide multidisciplinary training for physician and PhD investigators who will devote a significant component of their professional activity to understanding the pathophysiology and treatment of cardiovascular disease. This is the 6th renewal application for the University of Utah (UofU) Cardiovascular Research Training Program. Since its inception in 1984, this program has trained 112 individuals who have largely gone on to pursue research careers. During the last training period (2010-2015), this training grant supported 24 post-doctoral research trainees (8 MD/DOs, 1 MD/PhD, 15 PhDs) who all remain active at academic institutions. Our trainees have authored 157 publications, with an average of 2 first-author publications each. They have also received several grants and career development awards (e.g. NIH, American Heart Association). This program continues to build on our unique strengths in cardiovascular research at the UofU, spanning basic and mechanistic investigation across a range of model systems and translational studies in humans. This training program unifies the three major cardiovascular research centers at the UofU Health Sciences Center: The Molecular Medicine Program at the Eccles Institute of Human Genetics, Heart Failure and Regeneration Initiatives in the Divisions of Cardiovascular Medicine at the School of Medicine, and the Nora Eccles Harrison Cardiovascular Research and Training Institute that specializes in cardiac electrophysiology and ion transport. This training program spans 10 UofU departments and includes 33 well-funded faculty mentors who lead exciting and productive cardiovascular research programs. Each trainee will participate in a two-year training program that includes a research project with a multidisciplinary mentoring committee, didactic coursework, and professional development opportunities. With this renewal application, we continue to request support to prepare 8 postdoctoral trainees to be leaders in cardiovascular research. The next stage of the training program will utilize an expanded mentor pool and implement a dual-leadership structure (MPIs: Dean Li, MD, PhD, and Mike Sanguinetti, PhD), as well as new program activities to prepare our trainees for careers in cardiovascular research. The next five years of the training program will leverage new resources and opportunities at the UofU and represents a new era of interdisciplinary collaborative cardiovascular research at our institution.

Public Health Relevance

The need for well-trained investigators in the field of cardiovascular medicine is the justification for this program's existence and continuation. There are too few rigorously-trained cardiovascular investigators to take advantage of today's enormous growth in genetics, imaging, and technological advances. Since this program was first funded in 1984, the University of Utah has successfully trained over 100 cardiovascular investigators and is well-equipped to continue this success.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007576-33
Application #
9629730
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
1994-07-01
Project End
2022-01-31
Budget Start
2019-02-01
Budget End
2020-01-31
Support Year
33
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Wei, Peng; Dove, Katja K; Bensard, Claire et al. (2018) The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate. Trends Cell Biol 28:551-559
Abdul-Wajid, Sarah; Demarest, Bradley L; Yost, H Joseph (2018) Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish. Nat Commun 9:4603
Chaudhari, Akshay S; Fang, Zhongnan; Kogan, Feliks et al. (2018) Super-resolution musculoskeletal MRI using deep learning. Magn Reson Med 80:2139-2154
Gibbons, Eric K; Hodgson, Kyler K; Chaudhari, Akshay S et al. (2018) Simultaneous NODDI and GFA parameter map generation from subsampled q-space imaging using deep learning. Magn Reson Med :
Sommakia, Salah; Houlihan, Patrick R; Deane, Sadiki S et al. (2017) Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium. J Mol Cell Cardiol 113:22-32
Huang, Chao; Wasmund, Stephen; Hitchcock, Robert et al. (2017) Catheterized Fiber-Optics Confocal Microscopy of the Beating Heart In Situ. Circ Cardiovasc Imaging 10:
Zhu, Weiquan; Shi, Dallas S; Winter, Jacob M et al. (2017) Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy. J Clin Invest 127:4569-4582
Warren, Mark; Sciuto, Katie J; Taylor, Tyson G et al. (2017) Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart. Am J Physiol Heart Circ Physiol 312:H752-H767
Nielson, Jason R; Fredrickson, Eric K; Waller, T Cameron et al. (2017) Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria. Mol Cell 68:673-685.e6
Schlaberg, Robert; Queen, Krista; Simmon, Keith et al. (2017) Viral Pathogen Detection by Metagenomics and Pan-Viral Group Polymerase Chain Reaction in Children With Pneumonia Lacking Identifiable Etiology. J Infect Dis 215:1407-1415

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