This renewal application requests continued support for the training program in Hemostasis, Thrombosis and Vascular Biology at the University of Vermont. The focal point of the program is the basic and clinical research training of M.D. and Ph.D. fellows (4 Post-doctorals, 4 Pre-doctorals and 2 Short-term). It is our intent to maintain this highly integrated and symbiotic research environment which extends training opportunities to predoctoral and postdoctoral students. Postdoctoral candidates with an M.D. degree typically enter the program following the first year of residency training, while Ph.D. candidates usually begin training immediately after fulfilling their degree requirements. M.D. /Ph.D. candidates begin after the 2nd medical school year. Short-term medical students participate in the research program during summer breaks with preferences given to students who wish to return for several summers. The heart of the training program is the research programs of the training faculty;all of w h o m has well established programs involving aspects of hemostasis, thrombosis, blood chemistry and vascular biology. The program faculty includes the Chairs of the Departments of Biochemistry, Anatomy/Neurobiology and Pathology, and other distinguished faculty members. There is a high degree of cooperative interchange among the laboratories of the faculty members. The training faculty has complementary research interests and a long history of close interaction on both research and educational enterprises. Primary training of the fellows in this program occurs within the research laboratory environment and is supplemented with formal educational programs within the University of Vermont including Seminars, conferences, journal clubs, and laboratory meetings. Both formal (didactic) and informal (seminar) ethics programs are in place. This program provides trainees with a strong background in basic research skills and allows trainees to join a vast network of collaborating investigators, including the current and former members of the participating laboratories. Trainees are therefore well prepared for future research endeavors in any field.

Public Health Relevance

This program has a major focus on the training of investigators who will deal with blood clotting and bleeding disorders. This research area encompasses major health problems including venous thrombosis, myocardial infarction and hemophilia which collectively have significant morbidity and mortality in the American population.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Vermont & St Agric College
Schools of Medicine
United States
Zip Code
Olson, Nels C; Cushman, Mary; Judd, Suzanne E et al. (2015) American Heart Association's Life's Simple 7 and risk of venous thromboembolism: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. J Am Heart Assoc 4:e001494
Bouchard, Beth A; Chapin, John; Brummel-Ziedins, Kathleen E et al. (2015) Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency. Blood 125:3647-50
Olson, N C; Butenas, S; Lange, L A et al. (2015) Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study. J Thromb Haemost 13:1867-77
Gillett, Sarah R; Thacker, Evan L; Letter, Abraham J et al. (2015) Correlates of Incident Cognitive Impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Clin Neuropsychol 29:466-86
Alexander, Kristine S; Zakai, Neil A; Gillett, Sarah et al. (2014) ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort. Neurology 83:1271-6
Whelihan, Matthew F; Kiankhooy, Armin; Brummel-Ziedins, Kathleen E (2014) Thrombin generation and fibrin clot formation under hypothermic conditions: an in vitro evaluation of tissue factor initiated whole blood coagulation. J Crit Care 29:24-30
Lothrop, Adam P; Snider, Gregg W; Ruggles, Erik L et al. (2014) Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium? Biochemistry 53:554-65
Gillett, Sarah R; Boyle, Rebekah H; Zakai, Neil A et al. (2014) Validating laboratory results in a national observational cohort study without field centers: the Reasons for Geographic and Racial Differences in Stroke cohort. Clin Biochem 47:243-6
Gonzales, Albert L; Yang, Ying; Sullivan, Michelle N et al. (2014) A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Sci Signal 7:ra49
Olson, N C; Cushman, M; Lutsey, P L et al. (2014) Inflammation markers and incident venous thromboembolism: the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. J Thromb Haemost 12:1993-2001

Showing the most recent 10 out of 98 publications