This renewal application requests continued support for the training program in Hemostasis, Thrombosis and Vascular Biology at the University of Vermont. The focal point of the program is the basic and clinical research training of M.D. and Ph.D. fellows (4 Post-doctorals, 4 Pre-doctorals and 2 Short-term). It is our intent to maintain this highly integrated and symbiotic research environment which extends training opportunities to predoctoral and postdoctoral students. Postdoctoral candidates with an M.D. degree typically enter the program following the first year of residency training, while Ph.D. candidates usually begin training immediately after fulfilling their degree requirements. M.D. /Ph.D. candidates begin after the 2nd medical school year. Short-term medical students participate in the research program during summer breaks with preferences given to students who wish to return for several summers. The heart of the training program is the research programs of the training faculty;all of w h o m has well established programs involving aspects of hemostasis, thrombosis, blood chemistry and vascular biology. The program faculty includes the Chairs of the Departments of Biochemistry, Anatomy/Neurobiology and Pathology, and other distinguished faculty members. There is a high degree of cooperative interchange among the laboratories of the faculty members. The training faculty has complementary research interests and a long history of close interaction on both research and educational enterprises. Primary training of the fellows in this program occurs within the research laboratory environment and is supplemented with formal educational programs within the University of Vermont including Seminars, conferences, journal clubs, and laboratory meetings. Both formal (didactic) and informal (seminar) ethics programs are in place. This program provides trainees with a strong background in basic research skills and allows trainees to join a vast network of collaborating investigators, including the current and former members of the participating laboratories. Trainees are therefore well prepared for future research endeavors in any field.

Public Health Relevance

This program has a major focus on the training of investigators who will deal with blood clotting and bleeding disorders. This research area encompasses major health problems including venous thrombosis, myocardial infarction and hemophilia which collectively have significant morbidity and mortality in the American population.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Vermont & St Agric College
Schools of Medicine
United States
Zip Code
Lothrop, Adam P; Snider, Gregg W; Ruggles, Erik L et al. (2014) Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium? Biochemistry 53:554-65
Alexander, Kristine S; Zakai, Neil A; Gillett, Sarah et al. (2014) ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort. Neurology 83:1271-6
Gonzales, Albert L; Yang, Ying; Sullivan, Michelle N et al. (2014) A PLC?1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Sci Signal 7:ra49
Whelihan, Matthew F; Kiankhooy, Armin; Brummel-Ziedins, Kathleen E (2014) Thrombin generation and fibrin clot formation under hypothermic conditions: an in vitro evaluation of tissue factor initiated whole blood coagulation. J Crit Care 29:24-30
Hill-Eubanks, David C; Gonzales, Albert L; Sonkusare, Swapnil K et al. (2014) Vascular TRP channels: performing under pressure and going with the flow. Physiology (Bethesda) 29:343-60
Rumora, Amy E; Wang, Shu-Xia; Ferris, Lauren A et al. (2013) Structural basis of multisite single-stranded DNA recognition and ACTA2 repression by purine-rich element binding protein B (Pur*). Biochemistry 52:4439-50
Olson, Nels C; Sallam, Reem; Doyle, Margaret F et al. (2013) T helper cell polarization in healthy people: implications for cardiovascular disease. J Cardiovasc Transl Res 6:772-86
Haynes, Laura M; Dubief, Yves C; Mann, Kenneth G (2012) Membrane binding events in the initiation and propagation phases of tissue factor-initiated zymogen activation under flow. J Biol Chem 287:5225-34
Steere, Ashley N; Miller, Brendan F; Roberts, Samantha E et al. (2012) Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release. Biochemistry 51:686-94
Mann, Kenneth G (2011) Thrombin generation in hemorrhage control and vascular occlusion. Circulation 124:225-35

Showing the most recent 10 out of 87 publications