Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007602-06A1
Application #
3541395
Study Section
Research Manpower Review Committee (MR)
Project Start
1985-07-01
Project End
1996-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Malkowski, M G; Martin, P D; Lord, S T et al. (1997) Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16. Biochem J 326 ( Pt 3):815-22
Malkowski, M G; Martin, P D; Guzik, J C et al. (1997) The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. Protein Sci 6:1438-48
Malkowski, M G; Lazar, J B; Johnson, P H et al. (1997) The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence. J Mol Biol 266:367-80
Martin, P D; Malkowski, M G; DiMaio, J et al. (1996) Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues. Biochemistry 35:13030-9
Malkowski, M G; Wu, J Y; Lazar, J B et al. (1995) The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. J Biol Chem 270:7077-87
Stevens, D B; Swanborg, R H (1993) Bromodeoxyuridine and light treatment deletes effector but not suppressor cells of autoimmune encephalomyelitis. J Neuroimmunol 44:177-84
Stevens, D B; Karpus, W J; Gould, K E et al. (1992) Studies of V beta 8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J Neuroimmunol 37:123-9
Stern, M S; Vinogradov, S N; Sharma, P K et al. (1990) Amino acid sequence of the monomer subunit of the giant extracellular hemoglobin of the aquatic oligochaete, Tubifex tubifex. Eur J Biochem 194:67-73
Zafar, R S; Chow, L H; Stern, M S et al. (1990) The heterogeneity of the polymeric intracellular hemoglobin of Glycera dibranchiata and the cDNA-derived amino acid sequence of one component. Biochim Biophys Acta 1041:117-22
Bacon-Baguley, T; Ogilvie, M L; Gartner, T K et al. (1990) Thrombospondin binding to specific sequences within the A alpha- and B beta-chains of fibrinogen. J Biol Chem 265:2317-23

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