The objective of our competing renewal application for the University of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdisciplinary Program stems from the highly collaborative nature of our 43 well-funded faculties in 7 departments at the University of Chicago in 3 areas of concentration: Studies in Airway Biology continue to focus on airway inflammation, ain/vay smooth muscle and epithelial structure and function, B-cell and T-cell activation, and asthma genetics. These complement a new program of Studies in Pulmonary Fibrosis/Luna Transplantation that focuses on cellular and molecular mechanisms of fibrosis and on transplantation immunology. Studies in Critical Illness continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, protection against ischemic injury, and bedside translations to patients with sepsis or cardiopulmonary arrest. During the previous grant period, extremely strong programs in endothelial biology, pulmonary vascular disease, and acute lung injury were added. Complementing all 3 areas are new cross-cutting programs in systems biology draws on creative informatics and genetics tools, in translational medicine to speed improvement in human health, in research ethics to address advances in biotechnology and critical illness, and in nanomedicine to facilitate ultrastructural analyses and develop novel therapeutics. The Program Director is Julian Solway, MD, Prof of Medicine and Pediatrics, with Associate Directors Anne Sperling, PhD (Mentorship) and Steven White, MD (Administration). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisory Committees meet yearly to provide oversight and continuity of review, and an Admissions Committee meets bimonthly to review trainee progress. We request funding for 10 post-doctoral trainees. PhD and MD trainees are enrolled in approximately equal numbers and train together. All fellows perform full-time research for at least 2 years, and MD fellows will not receive clinical training while supported by this Program. Training consists of 4 major components: a Research Project performed under the direct supervision of faculty co-mentors;a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework;Learnina of Survival Skills that includes scientific communication, grant writing, and mentoring, and Multidisciplinarv Research. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007605-29
Application #
8495381
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
1985-06-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
29
Fiscal Year
2013
Total Cost
$653,160
Indirect Cost
$46,012
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Montgomery, Christopher P; Daniels, Melvin; Zhao, Fan et al. (2014) Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun 82:2125-34
Greenberg, J A; David, M Z; Pitrak, D L et al. (2014) Prior infections are associated with increased mortality from subsequent blood-stream infections among patients with hematological malignancies. Eur J Clin Microbiol Infect Dis 33:1615-21
Tjota, Melissa Y; Hrusch, Cara L; Blaine, Kelly M et al. (2014) Signaling through FcR?-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. J Allergy Clin Immunol 134:706-713.e8
O'Donnell 3rd, James J; Birukova, Anna A; Beyer, Eric C et al. (2014) Gap junction protein connexin43 exacerbates lung vascular permeability. PLoS One 9:e100931
Churpek, Matthew M; Yuen, Trevor C; Park, Seo Young et al. (2014) Using electronic health record data to develop and validate a prediction model for adverse outcomes in the wards*. Crit Care Med 42:841-8
Becker, Julia; Poroyko, Valeriy; Bhorade, Sangeeta (2014) The lung microbiome after lung transplantation. Expert Rev Respir Med 8:221-31
Kach, Jacob; Sandbo, Nathan; La, Jennifer et al. (2014) Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A. J Biol Chem 289:7505-13
Greenberg, Jared A; David, Michael Z; Hall, Jesse B et al. (2014) Immune dysfunction prior to Staphylococcus aureus bacteremia is a determinant of long-term mortality. PLoS One 9:e88197
Tjota, Melissa Y; Williams, Jesse W; Lu, Tiffany et al. (2013) IL-33-dependent induction of allergic lung inflammation by Fc?RIII signaling. J Clin Invest 123:2287-97
Churpek, Matthew M; Yuen, Trevor C; Edelson, Dana P (2013) Risk stratification of hospitalized patients on the wards. Chest 143:1758-65

Showing the most recent 10 out of 46 publications