This grant proposal deals with a training program in the area encompassing magnetic resonance (MR) technology and its applications in biomedical research. MR methods continue to make an enormous impact of various areas of biomedical research ranging from MR imaging (MRI) to functional studies of cognition to MR spectroscopy (MRS) and molecular structure. Exploiting these emerging technologies to their fullest extent requires the concomitant training of academic clinicians and basic scientists who can both advance these technologies and apply them to important clinical and research problems. The overall objective of this grant proposal is to provide concomitant training to academical clinicians and basic scientists at predoctoral and postdoctoral levels in the fundamentals of both basic and clinical MR research while giving equal representations to both disciplines. This will be accomplished by: (i) using of a dual mentor program: one preceptor in basic science and the other in clinical science, (ii) recruiting highly qualified trainees through a stringent recruiting policy, (iii) retaining a world class training faculty who are leading authorities in their research areas, (iv) providing constant interaction between the preceptors, the trainees, and the Program Director, and (v) ensuring access to state of the art research facilities and research opportunities at the frontiers of biomedical research. Accomplishment of the above goals provides all trainees with the necessary training to become independent scientists or academic clinicians and to enable them to pursue their independent careers and successfully compete for extramural funding.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007614-11
Application #
2802934
Study Section
Special Emphasis Panel (ZHL1-CSR-K (F1))
Project Start
1994-07-01
Project End
2004-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
11
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mawn, Theresa M; Popov, Anatoliy V; Beardsley, Nancy J et al. (2011) In vivo detection of phospholipase C by enzyme-activated near-infrared probes. Bioconjug Chem 22:2434-43
Milkevitch, Matthew; Beardsley, Nancy J; Delikatny, E James (2010) Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator-activated receptor gamma-dependent pathway. NMR Biomed 23:473-9
Milkevitch, Matthew; Jeitner, Thomas M; Beardsley, Nancy J et al. (2007) Lovastatin enhances phenylbutyrate-induced MR-visible glycerophosphocholine but not apoptosis in DU145 prostate cells. Biochim Biophys Acta 1771:1166-76
Liu, Chia-Shang J; Miki, Atsushi; Hulvershorn, Justin et al. (2006) Spatial and temporal characteristics of physiological noise in fMRI at 3T. Acad Radiol 13:313-23
Liu, C-S J; Bryan, R N; Miki, A et al. (2006) Magnocellular and parvocellular visual pathways have different blood oxygen level-dependent signal time courses in human primary visual cortex. AJNR Am J Neuroradiol 27:1628-34
Hulvershorn, Justin; Borthakur, Arijitt; Bloy, Luke et al. (2005) T1rho contrast in functional magnetic resonance imaging. Magn Reson Med 54:1155-62
Milkevitch, Matthew; Shim, Hyunsuk; Pilatus, Ulrich et al. (2005) Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells. Biochim Biophys Acta 1734:1-12
Hulvershorn, Justin; Bloy, Luke; Gualtieri, Eugene E et al. (2005) Spatial sensitivity and temporal response of spin echo and gradient echo bold contrast at 3 T using peak hemodynamic activation time. Neuroimage 24:216-23
Mawn, Theresa; Nioka, Shoko; Nijland, Mark et al. (2005) Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress. J Biomed Opt 10:064001
Hulvershorn, Justin; Bloy, Luke; Gualtieri, Eugene E et al. (2005) Temporal resolving power of spin echo and gradient echo fMRI at 3T with apparent diffusion coefficient compartmentalization. Hum Brain Mapp 25:247-58

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