The Training Program in Molecular and Translational Hematology is designed to prepare physicians and postdoctoral scientists for independent, research-oriented careers in hematology. The program draws on the research interests and expertise of 18 funded faculty members in the Divisions of Pediatric and Adult Hematology/Oncology, Departments of Pathology, Biological Chemistry, Molecular Medicine and Genetics, Cellular and Developmental Biology, Cellular and Molecular Biology, the Life Sciences Institute and the Howard Hughes Institute at the University of Michigan. Active areas of research include 1) molecular and cell biology of the immune system;2) molecular basis of neoplastic cell growth;3) molecular biology of hemostasis and thrombosis;and 4) translational research in blood and marrow transplantation. A Selection/Monitoring Committee recruits MD or PhD trainees with strong academic credentials who desire a scholarly career encompassing hematology teaching and research. MD trainees will have had 3 years of house officer training in Pediatrics or Internal Medicine and a year of clinical training in Pediatric or Adult Hematology/Oncology. PhD trainees will have a major interest in hematology-related research. Prior to starting in the laboratory, MD trainees are strongly encouraged to participate in a two-month Postgraduate Research Training Program in Cell and Molecular Biology. Trainees then spend 2-3 years in the lab under supervision of a faculty Lab Mentor, developing expertise in posing feasible scientific questions, acquiring skills to answer these questions, and critically evaluating data obtained. During their laboratory training, trainees are continuously mentored and evaluated semi-annually by a Mentoring Committee. Trainees present the results of their investigations, participate in discussions of data obtained by their colleagues, attend relevant research seminars and interact with faculty members in basic and translational sciences. During the course of training, each trainee is expected to author at least one research manuscript.

Public Health Relevance

The goal of this Program is to produce trainees successful in pursuing careers in academic hematology. Improved understanding of the mechanisms of hematologic diseases (including cancers such as leukemia and lymphoma) and of translational approaches of this improved understanding will lead to more effective and less toxic treatments for these conditions.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Rosebeck, S; Rehman, A O; Apel, I J et al. (2014) The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-?B signaling. Oncogene 33:2520-30
Kenneth, Niall S; Hucks Jr, George E; Kocab, Andrew J et al. (2014) Copper is a potent inhibitor of both the canonical and non-canonical NF?B pathways. Cell Cycle 13:1006-14
Krook, Melanie A; Nicholls, Lauren A; Scannell, Christopher A et al. (2014) Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res 12:953-64
Vander Lugt, Mark T; Braun, Thomas M; Hanash, Samir et al. (2013) ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med 369:529-39
Tran, Ivy T; Sandy, Ashley R; Carulli, Alexis J et al. (2013) Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest 123:1590-604
Levine, John E; Huber, Elisabeth; Hammer, Suntrea T G et al. (2013) Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality. Blood 122:1505-9
Harris, Andrew C; Kitko, Carrie L; Couriel, Daniel R et al. (2013) Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes. Haematologica 98:179-84
Harris, Andrew C; Ferrara, James L M; Braun, Thomas M et al. (2012) Plasma biomarkers of lower gastrointestinal and liver acute GVHD. Blood 119:2960-3
Rosebeck, Shaun; Rehman, Aasia O; Lucas, Peter C et al. (2011) From MALT lymphoma to the CBM signalosome: three decades of discovery. Cell Cycle 10:2485-96
Zacharias, William J; Madison, Blair B; Kretovich, Katherine E et al. (2011) Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol 355:152-62

Showing the most recent 10 out of 31 publications