Advances in our understanding and treatment of childhood respiratory disorders have been limited by a lack of insight into basic mechanisms of disease and the development of novel therapeutic strategies. The purpose of this program is to provide rigorous multidisciplinary training for academically oriented pediatricians interested in childhood lung diseases. This proposal is a reneal of the NIH Training Program in Pediatric Pulmonary Lung Disease at the University of Colorado School of Medicine, and represents the continuation of a well-established program that has ixisted since 1988. This current proposal has been expanded to represent the evolution of our training program and to refelct our highly interactive, multidisciplinary faculty. Strengths of this program include benefits derived from the integration of extensive resources of two collaborating hospitals (The Children's Hospital (TCH) and National Jewish Medical and Research Center (NJC)) and five research units at NJC and the UCHSC campus (Developmental Lung Biology Laboratory, Pediatric Heart Lung Center Laboratory, the Perinatal Research Facility, Regenerative Medicine and the Cardiovascular Pulmonary Laboratories). These resources are combined into a versatile training evnironment for both basic and applied research. Faculty in this program include the Pis of PPGs, SCCORs, a Therapeutic Development Center Award in Cystic Fibrosis, and NIH Clinical Research Center Grant, and several individual awards that address basic, applied and clinical research questions in the area of pulmonary biology. Collaborations between laboratory and clinical investigators are a major strength of this proposal, enhancing interactions between scientists and clinicians from diverse backgrounds and encouragaing """"""""bench to bedside"""""""" approaches to pediatric lung disease. All participants in the training program are full-time academic faculty, and include pediatric pulmonary and critical care physican- investigators, along with several basic (PhD) and other scientists from throughout the UCHSC. The most promising individuals with clearly defined academic goals are selected from candidates within our pediatric pulmonary, critical care and neonatology fellowship training programs. After a clinical year of training (funded from other sources), laboratory or clinical research experience is provided under the direct mentorship of a senior investigator. Structured course work in statistics, molecular biology, cell physiology, ethics, and other areas are provided to trainees.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007670-24
Application #
8296350
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O2))
Program Officer
Tigno, Xenia
Project Start
1994-07-15
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
24
Fiscal Year
2012
Total Cost
$394,508
Indirect Cost
$28,778
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Liptzin, Deborah R; Connell, Elisabeth A; Marable, Jennifer et al. (2016) Weaning nocturnal ventilation and decannulation in a pediatric ventilator care program. Pediatr Pulmonol 51:825-9
Seedorf, Gregory; Metoxen, Alexander J; Rock, Robert et al. (2016) Hepatocyte growth factor as a downstream mediator of vascular endothelial growth factor-dependent preservation of growth in the developing lung. Am J Physiol Lung Cell Mol Physiol 310:L1098-110
Mandell, Erica; Seedorf, Gregory J; Ryan, Sharon et al. (2015) Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1α-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol 309:L1018-26
Hoppe, Jordana E; Towler, Elinor; Wagner, Brandie D et al. (2015) Sputum induction improves detection of pathogens in children with cystic fibrosis. Pediatr Pulmonol 50:638-46
Fan, Leland L; Dishop, Megan K; Galambos, Csaba et al. (2015) Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme. Ann Am Thorac Soc 12:1498-505
Caverly, Lindsay J; Caceres, Silvia M; Fratelli, Cori et al. (2015) Mycobacterium abscessus morphotype comparison in a murine model. PLoS One 10:e0117657
Acker, Shannon N; Mandell, Erica W; Sims-Lucas, Sunder et al. (2015) Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr 166:178-83
Liptzin, Deborah R; Watson, Alan M; Murphy, Elissa et al. (2015) MUC5B expression and location in surfactant protein C mutations in children. Pediatr Pulmonol 50:1270-6
Mandell, Erica; Seedorf, Gregory; Gien, Jason et al. (2014) Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 306:L420-8
Martiniano, Stacey L; Sontag, Marci K; Daley, Charles L et al. (2014) Clinical significance of a first positive nontuberculous mycobacteria culture in cystic fibrosis. Ann Am Thorac Soc 11:36-44

Showing the most recent 10 out of 39 publications