The basic goals and objectives of this training grant competing renewal, that is, to provide 4 predoctoral and 5 postdoctoral students with outstanding training in cardiovascular physiology, are unchanged. Cardiovascular disease remains the primary cause of morbidity and mortality in the developed world. There continues to be a need for outstanding scientist-educators to increase our basic understanding of cardiovascular disease and to translate this information into clinical application. The 16 training-faculty are experienced mentors having trained 44 predoctoral and 89 postdoctoral students over the last ten-years. The faculty come from four different departments (3 basic science, one clinical) with a history of collaboration. Their areas of research extend from the atomic structure of signaling molecules to measurements of cardiac output in mice. Areas of concentration include K-channels, nicotinic receptors, second messengers, transcriptional control of myogenesis and development, and genetic bases of cardiovascular disease. A broad range of techniques are applied including electrophysiology, ligand binding, fluorescence spectroscopy, protein biochemicstry, fluorescence imaging, confocal microscopy, MRI, echo cardiography, DNA and protein sequencing, x-ray crystollography, cryomicroscopy, and transgenics. This ensures that trainees receive an integrated and interdisciplinary approach to the study of molecular excitability of the cardiovascular system. The didactic curriculum supports this broad view of physiology and includes classes in molecular and cellular biology as well as whole organ physiology. The training program equips trainees with skills to be effective educators. All trainees regularly present their research findings to the faculty and students and receive organized feedback. This improves their teaching skills as well as gives them opportunities to practice giving feedback. Our students participate in college-wide classes and workshops on didactic teaching, scientific writing and grant preparation. Over the last ten-years the program has trained 54 pre- and postdoctoral students. This success is due not only to the high-quality training that the students receive but also to the quality of the students recruited. Our training program and the college have established programs to aggressively seek qualified under represented minorities. We feel that our combination of faculty, curriculum and students will continue to yield high-quality scientist-educators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007676-20
Application #
7420901
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Scott, Jane
Project Start
1994-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2010-06-30
Support Year
20
Fiscal Year
2008
Total Cost
$335,580
Indirect Cost
Name
Baylor College of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Nikolaev, Sergey I; Vetiska, Sandra; Bonilla, Ximena et al. (2018) Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. N Engl J Med 378:250-261
Herman, Alexander M; Rhyner, Alexander M; Devine, W Patrick et al. (2018) A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open 7:
Tanner, Mark R; Pennington, Michael W; Chamberlain, Brayden H et al. (2018) Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. J Pharmacol Exp Ther 365:227-236
Loehr, James Anthony; Wang, Shang; Cully, Tanya R et al. (2018) NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. Elife 7:
Jarrett, Kelsey E; Lee, Ciaran; De Giorgi, Marco et al. (2018) Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol 38:1997-2006
Fish, Jason E; Cantu Gutierrez, Manuel; Dang, Lan T et al. (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development 144:2428-2444
Ren, Pingping; Hughes, Michael; Krishnamoorthy, Swapna et al. (2017) Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 7:12351
Brinegar, Amy E; Xia, Zheng; Loehr, James Anthony et al. (2017) Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife 6:
Quick, Ann P; Landstrom, Andrew P; Wang, Qiongling et al. (2017) Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci 2:56-67
Jarrett, Kelsey E; Lee, Ciaran M; Yeh, Yi-Hsien et al. (2017) Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep 7:44624

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