Cardiovascular disease remains the primary cause of morbidity and mortality in the developed world. There continues to be a need for outstanding scientist-educators to increase our basic understanding of cardiovascular disease and to translate this information into clinical application. The Training Program in """"""""Molecular Physiology of the Cardiovascular System"""""""" (MFCS) at Baylor College of Medicine is a multidisciplinary program with 32 participating faculty from 7 basic science and 9 clinical departments. The MFCS training program has trained 32 predoctoral and 68 postdoctoral trainees since its inception in 1989. Currently, the mentors are primarily located at Baylor College of Medicine (BCM), Rice University (RU), MD Anderson Cancer Center, Methodist Hospital, and the Texas A&M Health Sciences Center Institute for Biosciences and Biotechnology (IBT). The major goal for our program is to train biomedical scientists (5 predoctoral and 7 postdoctoral trainees) to work at the interface of basic and clinical research in one of four specialized themes, related to cardiovascular research. These themes include: 1) Electrophyslology & excitability, 2) Development and stem cells, 3) Stroke and cerebrovascular disease, and 4) Tissue engineering and novel therapeutic strategies. The strong collaborative research infrastructure at Baylor College of Medicine and partner institutions in the Texas Medical Center, and the diverse background of our mentors (basic scientists and practicing clinicians), provide unique resources for the trainees affiliated with the MFCS training program. The MFCS trainees will participate in an interdisciplinary training program comprised of didactic courses, grant writing workshops, journal clubs, seminar series, ethics training, and regular interactions with training faculty. Moreover, the pre- and postdoctoral fellows will be trained as leaders of teams of scientists and physicians that collaborate in translational research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
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Baylor College of Medicine
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United States
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Leach, John P; Heallen, Todd; Zhang, Min et al. (2017) Hippo pathway deficiency reverses systolic heart failure after infarction. Nature 550:260-264
Ren, Pingping; Hughes, Michael; Krishnamoorthy, Swapna et al. (2017) Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 7:12351
Quick, Ann P; Wang, Qiongling; Philippen, Leonne E et al. (2017) SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res 120:110-119
Quick, Ann P; Landstrom, Andrew P; Wang, Qiongling et al. (2017) Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci 2:56-67
Jarrett, Kelsey E; Lee, Ciaran M; Yeh, Yi-Hsien et al. (2017) Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep 7:44624
Wu, Darrell; Ren, Pingping; Zheng, Yanqiu et al. (2017) NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. Arterioscler Thromb Vasc Biol 37:694-706
Fortune, Ryan D; Grill, Raymond J; Beeton, Christine et al. (2017) Changes in Gene Expression and Metabolism in the Testes of the Rat following Spinal Cord Injury. J Neurotrauma 34:1175-1186
Tanner, Mark R; Tajhya, Rajeev B; Huq, Redwan et al. (2017) Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clin Immunol 180:45-57
Brinegar, Amy E; Xia, Zheng; Loehr, James Anthony et al. (2017) Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife 6:
Reynolds, Julia O; Quick, Ann P; Wang, Qiongling et al. (2016) Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol 225:371-380

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