Cardiovascular disease remains the leading cause of morbidity and mortality in t h e industrialized world. As such, there is a pronounced need to educate and train the next generation of scientists and physician-scientists focused on increasing our basic understanding of cardiovascular disease and translating these discoveries from the bench to the clinic. The Training Program in Molecular Physiology of the Cardiovascular System (MPCS) at Baylor College of Medicine is a multidisciplinary program composed of 26 faculty from 5 basic science and 5 clinical departments. The MPCS program has trained 41 pre-doctoral and 82 postdoctoral trainees since its inception in 1989. Although the majority of MPCS faculty members have primary appointments at BCM, several are at Rice University and UTHSC. MPCS's mission is to train biomedical scientists (5 pre-doctoral and 5 postdoctoral trainees) to work at the interface of basic and clinical research in one of three specialized areas related to cardiovascular research. These themes include: 1) Electrophysiology and cardiac arrhythmias, 2) Cardiovascular development and congenital disease, and 3) Tissue engineering, regenerative cardiology, and development of innovative methods for analysis and treatment of cardiovascular disease. The incredible collaborative research infrastructure at Baylor College of Medicine and partner institutions in the Texas Medical Center, combined with the diverse background of our mentors (basic scientists and practicing clinicians), provide an unrivalled environment for the scientific development, both in the classroom and at the bench, for MPCS trainees. The MPCS program consists of formal didactic courses, experimental planning and grant writing workshops, journal clubs, seminar series, ethics training, and regular interactions with training faculty for career guidance and development. Moreover, the pre- and postdoctoral fellows will be trained as leaders of teams of scientists and physicians that collaborate in translational research.

Public Health Relevance

Cardiovascular disease remains the primary cause of morbidity and mortality in the developed world. The Training Program in Molecular Physiology of the Cardiovascular System (MPCS) at Baylor College of Medicine provides an extremely unique educational environment combining expertise and training in technology, engineering, physiology and biology. We believe this unique combination of expertise is vital as we train the next generation of leaders in the cardiovascular field.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007676-26A1
Application #
9147690
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Huang, Li-Shin
Project Start
1994-07-01
Project End
2021-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
26
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Nikolaev, Sergey I; Vetiska, Sandra; Bonilla, Ximena et al. (2018) Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. N Engl J Med 378:250-261
Herman, Alexander M; Rhyner, Alexander M; Devine, W Patrick et al. (2018) A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open 7:
Tanner, Mark R; Pennington, Michael W; Chamberlain, Brayden H et al. (2018) Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. J Pharmacol Exp Ther 365:227-236
Loehr, James Anthony; Wang, Shang; Cully, Tanya R et al. (2018) NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. Elife 7:
Jarrett, Kelsey E; Lee, Ciaran; De Giorgi, Marco et al. (2018) Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol 38:1997-2006
Wu, Darrell; Ren, Pingping; Zheng, Yanqiu et al. (2017) NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. Arterioscler Thromb Vasc Biol 37:694-706
Pankowicz, Francis P; Jarrett, Kelsey E; Lagor, William R et al. (2017) CRISPR/Cas9: at the cutting edge of hepatology. Gut 66:1329-1340
Lee, Chang Seok; Hanna, Amy D; Wang, Hui et al. (2017) A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun 8:14659
Tanner, Mark R; Tajhya, Rajeev B; Huq, Redwan et al. (2017) Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clin Immunol 180:45-57
Fortune, Ryan D; Grill, Raymond J; Beeton, Christine et al. (2017) Changes in Gene Expression and Metabolism in the Testes of the Rat following Spinal Cord Injury. J Neurotrauma 34:1175-1186

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