Our program continues to have as its major objective to provide an interactive and Integrated environment for the generation of scientists with the ability to move through a continuum of investigations from molecular to cellular to tissue to organism level mechanisms. A theme of the program, which includes 38 trainers and 10 departments is training in the application of modern approaches including genomics, proteomics and protein chemistry, structure, and molecular dynamics, cellular mechanics and electrophysiology, computational biology, systems physiology including an understanding of the dynamics and activity of the heart and blood vessels. The program emphasizes translation of findings to the diagnosis, treatment, and prevention of disease. Sites of training include the University of Illinois at Chicago (UIC) and Rush University, which provides a unique and diverse training environment. Focus areas include endocrine, paracrine, autocrine, and mechanical signaling, electro-chemical coupling, channels, transporters and receptors, chemo-mechanical coupling structural biology, proteomics, signal transduction, genomics, gene regulation, translation and assembly, and Integration of signaling and systems biology. The program has a demonstrated history of providing an environment for trainees that includes multiple colloquia and seminars, and interactions and synergy among groups of trainers working individual or groups of trainees. Pre-doctoral candidates enter the program after a successful year of graduate study in the core curriculum of the UIC Graduate Education in Medical Sciences (GEMS) Program. They continue training in specialized areas including Bioengineering, Physiology and Biopphysics, Biological Chemistry and Molecular Biology, Cell Biology, and Pharmacolgy. The pre-doctoral curriculum is supplemented by required upper level graduate courses in areas of interest including Stem Cell Biology, Mass Spectrometry and Proteomics, Informatics, Control Theory, Systems and Computational Biology, and Techniques, Concepts, and Strategies of Scientific Enquiry. These courses include opportunities for evaluation and training in writing and presentation skills. The training of post-doctoral trainees includes two to three year programs tailored to their career objectives.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007692-23
Application #
8258759
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1990-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
23
Fiscal Year
2012
Total Cost
$439,204
Indirect Cost
$44,615
Name
University of Illinois at Chicago
Department
Physiology
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Baumgarten, Sarah C; Armouti, Marah; Ko, CheMyong et al. (2017) IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice. Endocrinology 158:2309-2318
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Bonds, Jacqueline A; Kuttner-Hirshler, Yafit; Bartolotti, Nancy et al. (2015) Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. PLoS One 10:e0131266
Convissar, Scott M; Bennett, Jill; Baumgarten, Sarah C et al. (2015) GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice. Biol Reprod 93:133
Grajales, Liliana; Lach, Lawrence E; Janisch, Patrick et al. (2015) Temporal expression of calcium channel subunits in satellite cells and bone marrow mesenchymal cells. Stem Cell Rev 11:408-22

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