Our program continues to have as its major objective to provide an interactive and Integrated environment for the generation of scientists with the ability to move through a continuum of investigations from molecular to cellular to tissue to organism level mechanisms. A theme of the program, which includes 38 trainers and 10 departments is training in the application of modern approaches including genomics, proteomics and protein chemistry, structure, and molecular dynamics, cellular mechanics and electrophysiology, computational biology, systems physiology including an understanding of the dynamics and activity of the heart and blood vessels. The program emphasizes translation of findings to the diagnosis, treatment, and prevention of disease. Sites of training include the University of Illinois at Chicago (UIC) and Rush University, which provides a unique and diverse training environment. Focus areas include endocrine, paracrine, autocrine, and mechanical signaling, electro-chemical coupling, channels, transporters and receptors, chemo-mechanical coupling structural biology, proteomics, signal transduction, genomics, gene regulation, translation and assembly, and Integration of signaling and systems biology. The program has a demonstrated history of providing an environment for trainees that includes multiple colloquia and seminars, and interactions and synergy among groups of trainers working individual or groups of trainees. Pre-doctoral candidates enter the program after a successful year of graduate study in the core curriculum of the UIC Graduate Education in Medical Sciences (GEMS) Program. They continue training in specialized areas including Bioengineering, Physiology and Biopphysics, Biological Chemistry and Molecular Biology, Cell Biology, and Pharmacolgy. The pre-doctoral curriculum is supplemented by required upper level graduate courses in areas of interest including Stem Cell Biology, Mass Spectrometry and Proteomics, Informatics, Control Theory, Systems and Computational Biology, and Techniques, Concepts, and Strategies of Scientific Enquiry. These courses include opportunities for evaluation and training in writing and presentation skills. The training of post-doctoral trainees includes two to three year programs tailored to their career objectives.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois at Chicago
Schools of Medicine
United States
Zip Code
Czysz, Andrew H; Schappi, Jeffrey M; Rasenick, Mark M (2015) Lateral diffusion of G?s in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Neuropsychopharmacology 40:766-73
Broughton, Kathleen M; Russell, Brenda (2015) Cardiomyocyte subdomain contractility arising from microenvironmental stiffness and topography. Biomech Model Mechanobiol 14:589-602
Baumgarten, Sarah C; Convissar, Scott M; Fierro, Michelle A et al. (2014) IGF1R signaling is necessary for FSH-induced activation of AKT and differentiation of human Cumulus granulosa cells. J Clin Endocrinol Metab 99:2995-3004
Alves, Marco L; Dias, Fernando A L; Gaffin, Robert D et al. (2014) Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins. Circ Cardiovasc Genet 7:132-43
Holmes, Michael V; Exeter, Holly J; Folkersen, Lasse et al. (2014) Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. Circ Cardiovasc Genet 7:144-50
Witayavanitkul, Namthip; Ait Mou, Younss; Kuster, Diederik W D et al. (2014) Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. J Biol Chem 289:8818-27
Kotlo, Kumar; Xing, Yongna; Lather, Sonia et al. (2014) PR65A phosphorylation regulates PP2A complex signaling. PLoS One 9:e85000
Doroudian, Golnar; Pinney, James; Ayala, Perla et al. (2014) Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes. Biomed Microdevices 16:705-15
Taglieri, Domenico M; Johnson, Keven R; Burmeister, Brian T et al. (2014) The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. J Mol Cell Cardiol 66:27-40
Monasky, Michelle M; Taglieri, Domenico M; Jacobson, Alice K et al. (2013) Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium. Arch Biochem Biophys 535:22-9

Showing the most recent 10 out of 153 publications