The objective of the Stanford training program in Vascular Medicine and Biology is to provide an enriched environment for the training and career development of young scientists and physicians, enabling them to learn and to apply cellular, molecular, genomic, biostatistical,, and/or epidemiological tools in vascular research. This training will be carried out in an environment of active clinical investigation in order to provide a broader perspective for the trainee and to assist him/her in identifying important problems of vascular medicine. Trainees will work in the laboratories of leading investigators in functional genomics; developmental, cell and vascular biology; vascular physiology and pharmacology; epidemiology and clinical investigation. They will become the future link between the various clinical and basic disciplines, and will stimulate collaborative activities in vascular research. To provide focus and organization, we have identified five major research initiatives that constitute the backbone of the training program. These initiatives represent major fields of vascular biology, in each of which our program has documented strengths and interdisciplinary interactions. Organizing the program along these research fields has solidified interactions, stimulated further collaborations, and provided structure for training. The major research initiatives are: 1) Vascular reactivity and structure; 2) Vascular Development and Angiogenesis; 3) Vascular inflammation; 4) Vascular disorders due to lipoprotein and glucose metabolism; and 5) Functional Genomics of Vascular Disease. This program provides the environment and the support for training academically oriented talented young physicians and scientists in vascular biology and medicine. These individuals are the future of this field; their successful development will contribute to the acceleration of basic insights in this area, and will facilitate the transfer of this knowledge into new therapeutic and diagnostic approaches to vascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007708-14
Application #
7070024
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Commarato, Michael
Project Start
1992-07-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
14
Fiscal Year
2006
Total Cost
$346,221
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Miyama, Noriyuki; Dua, Monica M; Yeung, Janice J et al. (2010) Hyperglycemia limits experimental aortic aneurysm progression. J Vasc Surg 52:975-83
Charo, David N; Ho, Michael; Fajardo, Giovanni et al. (2009) Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol 297:H1904-13
Zeini, Miriam; Hang, Calvin T; Lehrer-Graiwer, Joshua et al. (2009) Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development 136:3335-45
Spiekerkoetter, Edda; Guignabert, Christophe; de Jesus Perez, Vinicio et al. (2009) S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. Circ Res 105:639-47, 13 p following 647
Hansmann, Georg; de Jesus Perez, Vinicio A; Alastalo, Tero-Pekka et al. (2008) An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 118:1846-57
Potena, Luciano; Fearon, William F; Sydow, Karsten et al. (2008) Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus. Transplantation 85:827-33
Barrett, Curtis F; Tsien, Richard W (2008) The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels. Proc Natl Acad Sci U S A 105:2157-62
Fung, Eric T; Wilson, Andrew M; Zhang, Fujun et al. (2008) A biomarker panel for peripheral arterial disease. Vasc Med 13:217-24
Wilson, Andrew M; Kimura, Eiichiro; Harada, Randall K et al. (2007) Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies. Circulation 116:1396-403
Farin, H M F; Abbasi, F; Kim, S H et al. (2007) The relationship between insulin resistance and dyslipidaemia in cigarette smokers. Diabetes Obes Metab 9:65-9

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